Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Synaptic vesicular amine transporter (Rattus norvegicus (Rat)) | BDBM50433783 (CHEMBL2381721) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arkansas for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of VMAT2 in rat striatal synaptic vesicle assessed as reduction of [3H]dopamine uptake after 8 mins by liquid scintillation spectrometric ... | Bioorg Med Chem Lett 26: 2422-7 (2016) Article DOI: 10.1016/j.bmcl.2016.03.119 BindingDB Entry DOI: 10.7270/Q2BC41DT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Synaptic vesicular amine transporter (Rattus norvegicus (Rat)) | BDBM50433783 (CHEMBL2381721) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arkansas for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of VMAT2-mediated [3H]DA uptake in rat striatal synaptic vesicles by liquid scintillation spectroscopic analysis | Bioorg Med Chem Lett 23: 3342-5 (2013) Article DOI: 10.1016/j.bmcl.2013.03.092 BindingDB Entry DOI: 10.7270/Q2TD9ZR2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Synaptic vesicular amine transporter (Rattus norvegicus (Rat)) | BDBM50433783 (CHEMBL2381721) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arkansas for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of [3H]DA uptake at VMAT2 in rat striatal synaptic vesicles | Medchemcomm 4: 564-568 (2013) Article DOI: 10.1039/c3md20374c BindingDB Entry DOI: 10.7270/Q2KD21VD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50433783 (CHEMBL2381721) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 1.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arkansas for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of DAT in rat striatal synaptosomes assessed as reduction of [3H]dopamine uptake preincubated for 5 mins followed by [3H]dopamine addition... | Bioorg Med Chem Lett 26: 2422-7 (2016) Article DOI: 10.1016/j.bmcl.2016.03.119 BindingDB Entry DOI: 10.7270/Q2BC41DT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Synaptic vesicular amine transporter (Rattus norvegicus (Rat)) | BDBM50433783 (CHEMBL2381721) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 8.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arkansas for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of [3H]DTBZ binding to VMAT2 in rat synaptic vesicle membranes | Medchemcomm 4: 564-568 (2013) Article DOI: 10.1039/c3md20374c BindingDB Entry DOI: 10.7270/Q2KD21VD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Synaptic vesicular amine transporter (Rattus norvegicus (Rat)) | BDBM50433783 (CHEMBL2381721) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 8.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arkansas for Medical Sciences Curated by ChEMBL | Assay Description Displacement of [3H]DTBZ from VMAT2 in Sprague-Dawley rat synaptic vesicle membranes after 30 mins by scintillation counting analysis | Bioorg Med Chem Lett 23: 3342-5 (2013) Article DOI: 10.1016/j.bmcl.2013.03.092 BindingDB Entry DOI: 10.7270/Q2TD9ZR2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50433783 (CHEMBL2381721) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 9.36E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arkansas for Medical Sciences Curated by ChEMBL | Assay Description Inhibition of SERT in rat striatal synaptosomes assessed as reduction of [3H]5-HT uptake preincubated for 5 mins followed by [3H]5-HT addition measur... | Bioorg Med Chem Lett 26: 2422-7 (2016) Article DOI: 10.1016/j.bmcl.2016.03.119 BindingDB Entry DOI: 10.7270/Q2BC41DT | |||||||||||
More data for this Ligand-Target Pair |