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Found 1 hit Enz. Inhib. hit(s) with Target = '[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1,/2,/3,/4, mitochondrial' and Ligand = 'BDBM50472644'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1,/2,/3,/4, mitochondrial


(Homo sapiens (Human))		BDBM50472644
PNG
(CHEMBL74949)
Show SMILES COC(=O)c1ccc(NC(=O)C(C)(O)C(F)(F)F)c(Cl)c1
Show InChI InChI=1S/C12H11ClF3NO4/c1-11(20,12(14,15)16)10(19)17-8-4-3-6(5-7(8)13)9(18)21-2/h3-5,20H,1-2H3,(H,17,19)
PDB

UniProtKB/SwissProt

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GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 115n/an/an/an/an/an/a



Novartis Institute for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of porcine pyruvate dehydrogenase kinase (PDHK)in a primary enzymatic assay

J Med Chem 43: 2248-57 (2000)


Article DOI: 10.1021/jm0000923
BindingDB Entry DOI: 10.7270/Q2C82D1Z
More data for this
Ligand-Target Pair