BindingDB PrimarySearch

Found 4 hits Enz. Inhib. hit(s) with Target = '[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial' and Ligand = 'BDBM50177026'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (Homo sapiens (Human))	BDBM50177026 (CHEMBL3814630) Show SMILES FC(F)(F)c1cc(NC(=O)C(Cl)Cl)ccc1Cl Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	291	n/a	n/a	n/a	n/a	n/a
University of Macau Curated by ChEMBL					Assay Description Competitive binding affinity to recombinant N-terminal 6xHis-SUMO-tagged human PDK1 (29 to 436 residues) expressed in Escherichia coli BL-21 assessed...				J Med Chem 59: 3562-8 (2016) Article DOI: 10.1021/acs.jmedchem.5b01828 BindingDB Entry DOI: 10.7270/Q2P55QFZ
University of Macau Curated by ChEMBL					More data for this Ligand-Target Pair
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (Homo sapiens (Human))	BDBM50177026 (CHEMBL3814630) Show SMILES FC(F)(F)c1cc(NC(=O)C(Cl)Cl)ccc1Cl Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.08E+4	n/a	n/a	n/a	n/a	n/a
Vernalis (R&D) Ltd. Curated by ChEMBL					Assay Description Compound was evaluated for its dissociation constant (Kd) to guinea pig myometrial Oxytocin receptor				J Med Chem 60: 2271-2286 (2017) Article DOI: 10.1021/acs.jmedchem.6b01478 BindingDB Entry DOI: 10.7270/Q2XG9TDJ
Vernalis (R&D) Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (Homo sapiens (Human))	BDBM50177026 (CHEMBL3814630) Show SMILES FC(F)(F)c1cc(NC(=O)C(Cl)Cl)ccc1Cl Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	7.87E+3	n/a	n/a	n/a	n/a	n/a
University of Macau Curated by ChEMBL					Assay Description Competitive binding affinity to recombinant N-terminal 6xHis-SUMO-tagged human PDK1 (29 to 436 residues) expressed in Escherichia coli BL-21 assessed...				J Med Chem 59: 3562-8 (2016) Article DOI: 10.1021/acs.jmedchem.5b01828 BindingDB Entry DOI: 10.7270/Q2P55QFZ
University of Macau Curated by ChEMBL					More data for this Ligand-Target Pair
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (Homo sapiens (Human))	BDBM50177026 (CHEMBL3814630) Show SMILES FC(F)(F)c1cc(NC(=O)C(Cl)Cl)ccc1Cl Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.08E+4	n/a	n/a	n/a	n/a	n/a
University of Macau Curated by ChEMBL					Assay Description Binding affinity to recombinant N-terminal 6xHis-SUMO-tagged human PDK1 (29 to 436 residues) expressed in Escherichia coli BL-21 by isothermal titrat...				J Med Chem 59: 3562-8 (2016) Article DOI: 10.1021/acs.jmedchem.5b01828 BindingDB Entry DOI: 10.7270/Q2P55QFZ
University of Macau Curated by ChEMBL					More data for this Ligand-Target Pair