Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM13740'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM13740 (2-(benzylamino)-5-isopropyl-5-methylthiazol-4(5H)-...) Show SMILES CC(C)C1(C)SC(NCc2ccccc2)=NC1=O |c:15| Show InChI InChI=1S/C14H18N2OS/c1-10(2)14(3)12(17)16-13(18-14)15-9-11-7-5-4-6-8-11/h4-8,10H,9H2,1-3H3,(H,15,16,17)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	65	-40.6	n/a	n/a	n/a	n/a	n/a	7.2	22
Amgen					Assay Description Enzyme assays were performed using purified recombinant human or mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to det...				J Med Chem 50: 429-32 (2007) Article DOI: 10.1021/jm061214f BindingDB Entry DOI: 10.7270/Q20Z71JH
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