Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM250451'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM250451 (US9464044, 47) Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)C1(CC1)NS(=O)(=O)c1ccc(F)c(F)c1F)C(C3)C2 |r,wU:9.10,TLB:8:3:30:9.7.6,1:3:9:30.5.6,10:9:30:3.4.31,THB:8:7:30:3.4.31,4:3:9:30.5.6,4:5:9:3.8.31,(8.62,-1.04,;7.53,-2.13,;7.93,-3.62,;6.04,-1.73,;5.15,-3.66,;3.94,-2.99,;3.96,-.59,;4.72,.58,;6.04,-.19,;3.38,-.19,;2.05,.58,;.72,-.19,;.72,-1.73,;-.62,.58,;.15,1.91,;-1.39,1.91,;-1.95,-.19,;-3.29,.58,;-2.52,1.91,;-4.06,-.76,;-4.62,1.35,;-4.62,2.89,;-5.95,3.66,;-7.29,2.89,;-8.62,3.66,;-7.29,1.35,;-8.62,.58,;-5.95,.58,;-5.95,-.96,;3.38,-1.73,;2.55,-3.63,;4.72,-2.5,)| Show InChI InChI=1S/C21H24F3N3O4S/c22-13-1-2-14(16(24)15(13)23)32(30,31)27-21(3-4-21)19(29)26-17-11-5-10-6-12(17)9-20(7-10,8-11)18(25)28/h1-2,10-12,17,27H,3-9H2,(H2,25,28)(H,26,29)/t10?,11?,12?,17-,20?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	495	n/a	n/a	n/a	n/a	6.0	25
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION US Patent					Assay Description The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...				US Patent US9464044 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1JH0
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