Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM250483'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM250483 (US9464044, 116) Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)c4ccc(Br)cc4Cl)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:32:3.4.33,8:3:32:9.7.6,1:3:9:32.5.6,THB:8:7:32:3.4.33,4:3:9:32.5.6,4:5:9:3.8.33,(9.95,-.66,;8.87,-1.75,;9.26,-3.23,;7.38,-1.35,;6.48,-3.27,;5.28,-2.6,;5.29,-.2,;6.05,.96,;7.38,.19,;4.72,.19,;3.38,.96,;2.05,.19,;2.05,-1.35,;.72,.96,;.72,2.5,;-.62,3.27,;-1.95,2.5,;-1.95,.96,;-3.29,.19,;-4.62,.96,;-4.62,2.5,;-3.53,2.05,;-5.95,.19,;-5.95,-1.35,;-7.29,-2.12,;-8.62,-1.35,;-9.95,-2.12,;-8.62,.19,;-7.29,.96,;-7.29,2.5,;-.62,.19,;4.72,-1.35,;3.88,-3.25,;6.05,-2.12,)| Show InChI InChI=1S/C24H25BrClN3O4S/c25-17-4-5-20(19(26)9-17)34(32,33)29-18-3-1-2-14(8-18)22(30)28-21-15-6-13-7-16(21)12-24(10-13,11-15)23(27)31/h1-5,8-9,13,15-16,21,29H,6-7,10-12H2,(H2,27,31)(H,28,30)/t13?,15?,16?,21-,24?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	14.5	n/a	n/a	n/a	n/a	6.0	25
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION US Patent					Assay Description The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...				US Patent US9464044 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1JH0
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