Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM250497'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM250497 (US9464044, 138) Show SMILES NC(=O)C12CC3CC(C1)[C@H](NC(=O)c1cccc(NS(=O)(=O)C4CC4)c1)C(C3)C2 |r,wU:9.10,TLB:10:9:27:3.4.28,8:3:27:9.7.6,1:3:9:27.5.6,THB:8:7:27:3.4.28,4:3:9:27.5.6,4:5:9:3.8.28,(8.72,-.66,;7.63,-1.75,;8.03,-3.23,;6.15,-1.35,;5.25,-3.27,;4.05,-2.6,;4.06,-.2,;4.82,.96,;6.15,.19,;3.49,.19,;2.15,.96,;.82,.19,;.82,-1.35,;-.52,.96,;-.52,2.5,;-1.85,3.27,;-3.18,2.5,;-3.18,.96,;-4.52,.19,;-5.85,.96,;-5.85,2.5,;-7.18,1.73,;-7.18,.19,;-8.72,.19,;-7.95,-1.14,;-1.85,.19,;3.49,-1.35,;2.65,-3.25,;4.82,-2.12,)| Show InChI InChI=1S/C21H27N3O4S/c22-20(26)21-9-12-6-14(10-21)18(15(7-12)11-21)23-19(25)13-2-1-3-16(8-13)24-29(27,28)17-4-5-17/h1-3,8,12,14-15,17-18,24H,4-7,9-11H2,(H2,22,26)(H,23,25)/t12?,14?,15?,18-,21?	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	62.1	n/a	n/a	n/a	n/a	6.0	25
AHN-GOOK PHARMACEUTICAL CO., LTD.; BAMICHEM CO., LTD; INCHEON UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION US Patent					Assay Description The inhibiting activity of 11β-HSD1 derived from microsomal fractions was measured using the HTRF assay (62CO2PEB, Cisbio). Different concentrat...				US Patent US9464044 (2016) BindingDB Entry DOI: 10.7270/Q2SJ1JH0
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