Found 3 hits Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM50195503' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50195503
(4-amino-N-((1s,4s)-4-(benzylcarbamoyl)cyclohexyl)-...)Show SMILES Nc1c(Cl)cc(cc1Cl)C(=O)N(C1CC1)[C@H]1CC[C@H](CC1)C(=O)NCc1ccccc1 |wU:18.23,15.16,(32.12,-16.53,;30.78,-15.76,;30.78,-14.21,;32.11,-13.44,;29.44,-13.45,;28.11,-14.22,;28.11,-15.76,;29.45,-16.53,;29.45,-18.07,;26.78,-13.45,;26.78,-11.91,;25.45,-14.22,;24.11,-13.45,;23.35,-12.11,;22.58,-13.45,;25.45,-15.76,;26.78,-16.53,;26.78,-18.07,;25.44,-18.84,;24.11,-18.06,;24.11,-16.53,;25.43,-20.38,;24.1,-21.14,;26.76,-21.15,;26.76,-22.69,;28.09,-23.47,;28.07,-25.01,;29.4,-25.78,;30.74,-25.02,;30.74,-23.47,;29.41,-22.7,)| Show InChI InChI=1S/C24H27Cl2N3O2/c25-20-12-17(13-21(26)22(20)27)24(31)29(19-10-11-19)18-8-6-16(7-9-18)23(30)28-14-15-4-2-1-3-5-15/h1-5,12-13,16,18-19H,6-11,14,27H2,(H,28,30)/t16-,18+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 expressed in Escherichia coli by SPA |
Bioorg Med Chem Lett 16: 6241-5 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.035
BindingDB Entry DOI: 10.7270/Q2B857R4 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Rattus norvegicus (rat)) | BDBM50195503
(4-amino-N-((1s,4s)-4-(benzylcarbamoyl)cyclohexyl)-...)Show SMILES Nc1c(Cl)cc(cc1Cl)C(=O)N(C1CC1)[C@H]1CC[C@H](CC1)C(=O)NCc1ccccc1 |wU:18.23,15.16,(32.12,-16.53,;30.78,-15.76,;30.78,-14.21,;32.11,-13.44,;29.44,-13.45,;28.11,-14.22,;28.11,-15.76,;29.45,-16.53,;29.45,-18.07,;26.78,-13.45,;26.78,-11.91,;25.45,-14.22,;24.11,-13.45,;23.35,-12.11,;22.58,-13.45,;25.45,-15.76,;26.78,-16.53,;26.78,-18.07,;25.44,-18.84,;24.11,-18.06,;24.11,-16.53,;25.43,-20.38,;24.1,-21.14,;26.76,-21.15,;26.76,-22.69,;28.09,-23.47,;28.07,-25.01,;29.4,-25.78,;30.74,-25.02,;30.74,-23.47,;29.41,-22.7,)| Show InChI InChI=1S/C24H27Cl2N3O2/c25-20-12-17(13-21(26)22(20)27)24(31)29(19-10-11-19)18-8-6-16(7-9-18)23(30)28-14-15-4-2-1-3-5-15/h1-5,12-13,16,18-19H,6-11,14,27H2,(H,28,30)/t16-,18+ | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 39 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of rat 11beta-HSD1 |
Bioorg Med Chem Lett 16: 6241-5 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.035
BindingDB Entry DOI: 10.7270/Q2B857R4 |
More data for this
Ligand-Target Pair | |
11-beta-hydroxysteroid dehydrogenase 1
(Homo sapiens (Human)) | BDBM50195503
(4-amino-N-((1s,4s)-4-(benzylcarbamoyl)cyclohexyl)-...)Show SMILES Nc1c(Cl)cc(cc1Cl)C(=O)N(C1CC1)[C@H]1CC[C@H](CC1)C(=O)NCc1ccccc1 |wU:18.23,15.16,(32.12,-16.53,;30.78,-15.76,;30.78,-14.21,;32.11,-13.44,;29.44,-13.45,;28.11,-14.22,;28.11,-15.76,;29.45,-16.53,;29.45,-18.07,;26.78,-13.45,;26.78,-11.91,;25.45,-14.22,;24.11,-13.45,;23.35,-12.11,;22.58,-13.45,;25.45,-15.76,;26.78,-16.53,;26.78,-18.07,;25.44,-18.84,;24.11,-18.06,;24.11,-16.53,;25.43,-20.38,;24.1,-21.14,;26.76,-21.15,;26.76,-22.69,;28.09,-23.47,;28.07,-25.01,;29.4,-25.78,;30.74,-25.02,;30.74,-23.47,;29.41,-22.7,)| Show InChI InChI=1S/C24H27Cl2N3O2/c25-20-12-17(13-21(26)22(20)27)24(31)29(19-10-11-19)18-8-6-16(7-9-18)23(30)28-14-15-4-2-1-3-5-15/h1-5,12-13,16,18-19H,6-11,14,27H2,(H,28,30)/t16-,18+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of human 11beta-HSD1 expressed in HEK293 cells by fluorescence polarization immuno-assay |
Bioorg Med Chem Lett 16: 6241-5 (2006)
Article DOI: 10.1016/j.bmcl.2006.09.035
BindingDB Entry DOI: 10.7270/Q2B857R4 |
More data for this
Ligand-Target Pair | |
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