Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM99339'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM99339 (US8497281, 50 | US9120769, 50 | US9663470, 50) Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2CC(=O)Nc2c1 |r| Show InChI InChI=1S/C22H22N2O2/c25-21-13-15-7-8-16(12-19(15)23-21)22(26)24-11-3-6-18-17-5-2-1-4-14(17)9-10-20(18)24/h1-2,4-5,7-8,12,18,20H,3,6,9-11,13H2,(H,23,25)/t18?,20-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.27E+3	n/a	n/a	n/a	n/a	6.0	37
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...				US Patent US8497281 (2013) BindingDB Entry DOI: 10.7270/Q2G44NXT
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM99339 (US8497281, 50 | US9120769, 50 | US9663470, 50) Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2CC(=O)Nc2c1 |r| Show InChI InChI=1S/C22H22N2O2/c25-21-13-15-7-8-16(12-19(15)23-21)22(26)24-11-3-6-18-17-5-2-1-4-14(17)9-10-20(18)24/h1-2,4-5,7-8,12,18,20H,3,6,9-11,13H2,(H,23,25)/t18?,20-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.27E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh US Patent					Assay Description In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...				US Patent US9663470 (2017) BindingDB Entry DOI: 10.7270/Q2V40X8H
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM99339 (US8497281, 50 | US9120769, 50 | US9663470, 50) Show SMILES O=C(N1CCCC2[C@@H]1CCc1ccccc21)c1ccc2CC(=O)Nc2c1 |r| Show InChI InChI=1S/C22H22N2O2/c25-21-13-15-7-8-16(12-19(15)23-21)22(26)24-11-3-6-18-17-5-2-1-4-14(17)9-10-20(18)24/h1-2,4-5,7-8,12,18,20H,3,6,9-11,13H2,(H,23,25)/t18?,20-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.27E+3	n/a	n/a	n/a	n/a	6.0	n/a
Boehringer-Ingelheim International GmbH US Patent					Assay Description n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...				US Patent US9120769 (2015) BindingDB Entry DOI: 10.7270/Q2XW4HK9
					More data for this Ligand-Target Pair