Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1' and Ligand = 'BDBM99407'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM99407 (US8497281, 185 | US9120769, 118 | US9663470, 118) Show SMILES Cn1nnc2cc(ccc12)C(=O)N1CCCC2[C@@H]1Cc1ccccc21 |r| Show InChI InChI=1S/C20H20N4O/c1-23-18-9-8-14(11-17(18)21-22-23)20(25)24-10-4-7-16-15-6-3-2-5-13(15)12-19(16)24/h2-3,5-6,8-9,11,16,19H,4,7,10,12H2,1H3/t16?,19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.07E+3	n/a	n/a	n/a	n/a	6.0	37
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...				US Patent US8497281 (2013) BindingDB Entry DOI: 10.7270/Q2G44NXT
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM99407 (US8497281, 185 | US9120769, 118 | US9663470, 118) Show SMILES Cn1nnc2cc(ccc12)C(=O)N1CCCC2[C@@H]1Cc1ccccc21 |r| Show InChI InChI=1S/C20H20N4O/c1-23-18-9-8-14(11-17(18)21-22-23)20(25)24-10-4-7-16-15-6-3-2-5-13(15)12-19(16)24/h2-3,5-6,8-9,11,16,19H,4,7,10,12H2,1H3/t16?,19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.07E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh US Patent					Assay Description In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...				US Patent US9663470 (2017) BindingDB Entry DOI: 10.7270/Q2V40X8H
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM99407 (US8497281, 185 | US9120769, 118 | US9663470, 118) Show SMILES Cn1nnc2cc(ccc12)C(=O)N1CCCC2[C@@H]1Cc1ccccc21 |r| Show InChI InChI=1S/C20H20N4O/c1-23-18-9-8-14(11-17(18)21-22-23)20(25)24-10-4-7-16-15-6-3-2-5-13(15)12-19(16)24/h2-3,5-6,8-9,11,16,19H,4,7,10,12H2,1H3/t16?,19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.07E+3	n/a	n/a	n/a	n/a	6.0	n/a
Boehringer-Ingelheim International GmbH US Patent					Assay Description n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...				US Patent US9120769 (2015) BindingDB Entry DOI: 10.7270/Q2XW4HK9
					More data for this Ligand-Target Pair