Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E]' and Ligand = 'BDBM32502'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E] (Homo sapiens (Human))	BDBM32502 (pyridine amide, 17) Show SMILES CC1CCN(CC1)C(=O)c1cc(CS(=O)(=O)c2c(Cl)cccc2Cl)ccn1 Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-6-9-23(10-7-13)19(24)17-11-14(5-8-22-17)12-27(25,26)18-15(20)3-2-4-16(18)21/h2-5,8,11,13H,6-7,9-10,12H2,1H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	319	n/a	n/a	n/a	n/a	6.5	23
Bristol-Myers Squibb Company					Assay Description 11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...				Bioorg Med Chem Lett 18: 3168-72 (2008) Article DOI: 10.1016/j.bmcl.2008.04.069 BindingDB Entry DOI: 10.7270/Q2P26WGT
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