Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = '11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E]' and Ligand = 'BDBM32510'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E] (Homo sapiens (Human))	BDBM32510 (pyridine amide, 25) Show SMILES NC(=O)C1CCN(CC1)C(=O)c1cncc(CS(=O)(=O)c2c(Cl)cccc2Cl)c1 Show InChI InChI=1S/C19H19Cl2N3O4S/c20-15-2-1-3-16(21)17(15)29(27,28)11-12-8-14(10-23-9-12)19(26)24-6-4-13(5-7-24)18(22)25/h1-3,8-10,13H,4-7,11H2,(H2,22,25)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.35E+3	n/a	n/a	n/a	n/a	6.5	23
Bristol-Myers Squibb Company					Assay Description 11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...				Bioorg Med Chem Lett 18: 3168-72 (2008) Article DOI: 10.1016/j.bmcl.2008.04.069 BindingDB Entry DOI: 10.7270/Q2P26WGT
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