Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM50368147 ((+)-(3R,5S)-fluvastatin | (3R,5S)-fluvastatin | (3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hoechst AG Curated by ChEMBL | Assay Description In vitro inhibition of solubilized HMG-CoA reductase in rat liver. | J Med Chem 34: 2962-83 (1991) BindingDB Entry DOI: 10.7270/Q2C829WX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM50368147 ((+)-(3R,5S)-fluvastatin | (3R,5S)-fluvastatin | (3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
R. W. Johnson Pharmaceutical Research Institute Curated by ChEMBL | Assay Description Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0015-0.0040 | J Med Chem 36: 3674-85 (1994) BindingDB Entry DOI: 10.7270/Q2R78FVG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM50368147 ((+)-(3R,5S)-fluvastatin | (3R,5S)-fluvastatin | (3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Inhibition of rat HMG-CoA reductase using 0.37 MBq DL-[3-14C]HMG-CoA | Bioorg Med Chem Lett 19: 4228-31 (2009) Article DOI: 10.1016/j.bmcl.2009.05.100 BindingDB Entry DOI: 10.7270/Q22F7PCK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Homo sapiens (Human)) | BDBM50368147 ((+)-(3R,5S)-fluvastatin | (3R,5S)-fluvastatin | (3...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Pharmaceutical Education and Research (NIPER) Curated by ChEMBL | Assay Description Inhibitory concentration against 3-hydroxy-3-methylglutaryl-CoA reductase | Bioorg Med Chem Lett 15: 1027-32 (2005) Article DOI: 10.1016/j.bmcl.2004.12.042 BindingDB Entry DOI: 10.7270/Q2TB17N9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM50368147 ((+)-(3R,5S)-fluvastatin | (3R,5S)-fluvastatin | (3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Ability to inhibit microsomal preparation of HMG-CoA reductase in rat liver. | J Med Chem 34: 463-6 (1991) BindingDB Entry DOI: 10.7270/Q2MS3TC4 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |