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Found 1 hit Enz. Inhib. hit(s) with Target = '3-oxo-5-alpha-steroid 4-dehydrogenase 1' and Ligand = 'BDBM50070049'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-oxo-5-alpha-steroid 4-dehydrogenase 1


(Homo sapiens (Human))		BDBM50070049
PNG
((4aR,10bR)-4,10b-Dimethyl-8-((Z)-styryl)-1,4,4a,5,...)
Show SMILES CN1[C@@H]2CCc3cc(\C=C/c4ccccc4)ccc3[C@@]2(C)CCC1=O
Show InChI InChI=1S/C23H25NO/c1-23-15-14-22(25)24(2)21(23)13-11-19-16-18(10-12-20(19)23)9-8-17-6-4-3-5-7-17/h3-10,12,16,21H,11,13-15H2,1-2H3/b9-8-/t21-,23-/m1/s1
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PubMed
n/an/a 6n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against Steroid 5-alpha-reductase type I enzyme based on the conversion of [3H]-T to [3H]-DHT in nuclear membrane preparations fr...

Bioorg Med Chem Lett 8: 395-8 (1999)


BindingDB Entry DOI: 10.7270/Q2CN732C
More data for this
Ligand-Target Pair