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Found 1 hit Enz. Inhib. hit(s) with Target = '3-phosphoinositide-dependent protein kinase 1 [51-360]' and Ligand = 'BDBM366216'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3-phosphoinositide-dependent protein kinase 1 [51-360]


(Homo sapiens (Human))		BDBM366216
PNG
(US9873693, Compound 139)
Show SMILES FC(F)(F)c1ccc(Cn2cc(Cl)cc(C(=O)NCc3noc(n3)-c3c[nH]c4ncccc34)c2=O)cc1
Show InChI InChI=1S/C24H16ClF3N6O3/c25-15-8-17(23(36)34(12-15)11-13-3-5-14(6-4-13)24(26,27)28)21(35)31-10-19-32-22(37-33-19)18-9-30-20-16(18)2-1-7-29-20/h1-9,12H,10-11H2,(H,29,30)(H,31,35)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Duquesne University



Assay Description
A PDK1 kinase assay was performed as follows. PDK1 (amino acids 51-360) and AKT2 (amino acids 140-467 fused to PIFtide, amino acids EEQEMFRDFDYIADW) ...

J Med Chem 51: 68-76 (2008)


BindingDB Entry DOI: 10.7270/Q2H41TRT
More data for this
Ligand-Target Pair