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Target
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Compile Data Set for Download or QSAR
Found
4
hits Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 1D' and Ligand = 'BDBM50007407'
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human))
BDBM50007407
(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Show SMILES
C1CN(CCN1)c1cccc2ccccc12
Show InChI
InChI=1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
Article
PubMed
6.20
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Centre de Recherche Pierre FABRE
Curated by
ChEMBL
Assay Description
Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cells
J Med Chem
40:
3974
-
8
(1998)
Article DOI:
10.1021/jm9703552
BindingDB Entry DOI:
10.7270/Q2FT8K57
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human))
BDBM50007407
(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Show SMILES
C1CN(CCN1)c1cccc2ccccc12
Show InChI
InChI=1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
PubMed
6.20
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Centre de Recherche Pierre FABRE
Curated by
ChEMBL
Assay Description
Binding affinity of the compound was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligand
Bioorg Med Chem Lett
8:
1407
-
12
(1999)
BindingDB Entry DOI:
10.7270/Q2SQ8ZJS
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human))
BDBM50007407
(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Show SMILES
C1CN(CCN1)c1cccc2ccccc12
Show InChI
InChI=1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
Article
PubMed
7.41
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
University of Alberta
Curated by
PDSP K
i
Database
Neuropharmacology
33:
275
-
317
(1994)
Article DOI:
10.1016/0028-3908(94)90059-0
BindingDB Entry DOI:
10.7270/Q2M043X2
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human))
BDBM50007407
(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Show SMILES
C1CN(CCN1)c1cccc2ccccc12
Show InChI
InChI=1S/C14H16N2/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16/h1-7,15H,8-11H2
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
Article
PubMed
12
n/a
n/a
n/a
n/a
n/a
n/a
n/a
n/a
Synaptic Pharmaceutical Corporation
Curated by
PDSP K
i
Database
Proc Natl Acad Sci U S A
89:
3630
-
4
(1992)
Article DOI:
10.1073/pnas.89.8.3630
BindingDB Entry DOI:
10.7270/Q2VH5M9X
More data for this
Ligand-Target Pair