Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 3A/3B (Rattus norvegicus-RAT) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | Article | 158 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Tested for its binding affinity by measuring its ability to displace [3H]granisetron from 5-hydroxytryptamine 3 receptor in rat cortex | Bioorg Med Chem Lett 3: 633-634 (1993) Article DOI: 10.1016/S0960-894X(01)81243-9 BindingDB Entry DOI: 10.7270/Q23T9JD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A/3B (Rattus norvegicus-RAT) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | PubMed | 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merrell Dow Research Institute Curated by ChEMBL | Assay Description Binding affinity to 5-hydroxytryptamine 3 receptor entirely in guinea pig ileum | J Med Chem 33: 1594-600 (1990) BindingDB Entry DOI: 10.7270/Q25Q4X94 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A/3B (Rattus norvegicus-RAT) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | Article PubMed | 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co. Ltd. Curated by ChEMBL | Assay Description Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptor | J Med Chem 46: 702-15 (2003) Article DOI: 10.1021/jm020270n BindingDB Entry DOI: 10.7270/Q25H7H06 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A/3B (Rattus norvegicus-RAT) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | PubMed | 229 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merrell Dow Research Institute Curated by ChEMBL | Assay Description Potency at neuronal 5-hydroxytryptamine 3 receptor in the rabbit heart | J Med Chem 33: 1594-600 (1990) BindingDB Entry DOI: 10.7270/Q25Q4X94 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A/3B (Rattus norvegicus-RAT) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | PubMed | 240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Searle Research and Development Curated by ChEMBL | Assay Description Inhibition of [3H]GR-65630 binding to 5-hydroxytryptamine 3 receptor | J Med Chem 35: 1486-9 (1992) BindingDB Entry DOI: 10.7270/Q2CC11B3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A/3B (Rattus norvegicus-RAT) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | Article PubMed | 348 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Louis Pasteur Curated by ChEMBL | Assay Description Compound was evaluated for its binding affinity for 5-hydroxytryptamine 3 receptor by measuring displacement [3H]GR-65630 in rat cerebral cortex | J Med Chem 41: 311-7 (1998) Article DOI: 10.1021/jm9705418 BindingDB Entry DOI: 10.7270/Q2N29XMV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A/3B (Rattus norvegicus-RAT) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | Article | 443 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity against 5-hydroxytryptamine 3 receptor using [3H]BRL-43694 as radioligand in rat posterior cortex | Bioorg Med Chem Lett 5: 795-798 (1995) Article DOI: 10.1016/0960-894X(95)00115-A BindingDB Entry DOI: 10.7270/Q2R78FP7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A/3B (Rattus norvegicus-RAT) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | Article | 443 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity against 5-hydroxytryptamine 3 receptor using [3H]-BRL-43694 in rat posterior cortex | Bioorg Med Chem Lett 4: 1433-1436 (1994) Article DOI: 10.1016/S0960-894X(01)80508-4 BindingDB Entry DOI: 10.7270/Q2G160RF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A/3B (Rattus norvegicus-RAT) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | Article | 490 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Binding affinity at 5-hydroxytryptamine 3 receptor in rat entorhinal cortex by [3H]BRL-43694 displacement. | Bioorg Med Chem Lett 6: 263-266 (1996) Article DOI: 10.1016/0960-894X(96)00002-9 BindingDB Entry DOI: 10.7270/Q2MC90JK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A/3B (Rattus norvegicus-RAT) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | PubMed | 501 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description pKi value for inhibition of [3H]LY-278584 binding to 5-hydroxytryptamine 3 receptor | J Med Chem 33: 3176-81 (1991) BindingDB Entry DOI: 10.7270/Q2TM7BQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A/3B (Rattus norvegicus-RAT) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | PubMed | 502 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against 5-hydroxytryptamine 3 receptor in rat cortical membranes using [3H]- 1-Methyl-1H-indazole-3-carboxylic acid (8-methyl-8-a... | J Med Chem 33: 3176-81 (1991) BindingDB Entry DOI: 10.7270/Q2TM7BQG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A/3B (Rattus norvegicus-RAT) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | PubMed | 995 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL | Assay Description Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes. | J Med Chem 35: 895-903 (1992) BindingDB Entry DOI: 10.7270/Q2SJ1M77 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A/3B (Rattus norvegicus-RAT) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 228 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co. Ltd. Curated by ChEMBL | Assay Description Concentration required to inhibit the binding of radioligand [3H]GR-65630 to serotonin 5-hydroxytryptamine-3 receptor (5-HT 3 receptor)in rat brain c... | J Med Chem 46: 702-15 (2003) Article DOI: 10.1021/jm020270n BindingDB Entry DOI: 10.7270/Q25H7H06 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A/3B (Rattus norvegicus-RAT) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Inhibition of [3H]- GR 65630 binding to rat cortical membrane 5-hydroxytryptamine 3 receptor | Bioorg Med Chem Lett 8: 1551-4 (1999) BindingDB Entry DOI: 10.7270/Q2CF9P7B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A/3B (Rattus norvegicus-RAT) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Pharmaceutical Co., Ltd. Curated by ChEMBL | Assay Description Binding affinity against 5-hydroxytryptamine 3 receptor in rat cortical membrane using [3H]GR-65630 as radioligand | Bioorg Med Chem Lett 8: 619-24 (1999) BindingDB Entry DOI: 10.7270/Q25Q4WN6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 3A/3B (Mus musculus (house mouse)) | BDBM48320 (4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-metho...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase DrugBank KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 224 | n/a | n/a | n/a | n/a | n/a |
Merrell Dow Research Institute Curated by ChEMBL | Assay Description Potency to 5-hydroxytryptamine 3 receptor entirely in guinea pig ileum | J Med Chem 33: 1594-600 (1990) BindingDB Entry DOI: 10.7270/Q25Q4X94 | |||||||||||
More data for this Ligand-Target Pair |