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Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 4' and Ligand = 'BDBM50056412'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 4


(RAT)
BDBM50056412
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-pyrrolid...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC1
Show InChI InChI=1S/C14H19ClN2O3/c1-19-13-9-12(16)11(15)8-10(13)14(18)20-7-6-17-4-2-3-5-17/h8-9H,2-7,16H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.40n/an/an/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
Binding affinity towards 5-hydroxytryptamine 4 receptor was determined in rat striatal membranes using [3H]GR-113808 as radioligand


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(GUINEA PIG)
BDBM50056412
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-pyrrolid...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC1
Show InChI InChI=1S/C14H19ClN2O3/c1-19-13-9-12(16)11(15)8-10(13)14(18)20-7-6-17-4-2-3-5-17/h8-9H,2-7,16H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
5-hydroxytryptamine 4 receptor antagonist activity, concentration which gave 50% reduction of the 5-HT-induced contractions in the guinea pig ileum


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4


(GUINEA PIG)
BDBM50056412
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-pyrrolid...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCCC1
Show InChI InChI=1S/C14H19ClN2O3/c1-19-13-9-12(16)11(15)8-10(13)14(18)20-7-6-17-4-2-3-5-17/h8-9H,2-7,16H2,1H3
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 40n/an/an/an/a



CNRS-BIOCIS

Curated by ChEMBL


Assay Description
5-hydroxytryptamine 4 receptor agonist activity, concentration which gave 50% increase in the response to electrically-stimulated myenteric plexus an...


J Med Chem 40: 608-21 (1997)


Article DOI: 10.1021/jm960320m
BindingDB Entry DOI: 10.7270/Q2T72J36
More data for this
Ligand-Target Pair