Found 15 hits Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 6' and Ligand = 'BDBM50090528' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 6
(RAT) | BDBM50090528
(4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-b...)Show InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) | PDB
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| 28.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by PDSP Ki Database
| |
Mol Pharmacol 64: 1295-308 (2003)
Article DOI: 10.1124/mol.64.6.1295 BindingDB Entry DOI: 10.7270/Q2BP01CZ |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50090528
(4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-b...)Show InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) | PDB
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| 44.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratorios Dr. Esteve S.A.
Curated by ChEMBL
| Assay Description Inhibition of [3H]-LSD binding to human 5-hydroxytryptamine 6 receptor expressed in HEK293 cells |
J Med Chem 48: 1781-95 (2005)
Article DOI: 10.1021/jm049615n BindingDB Entry DOI: 10.7270/Q2ZP45N9 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50090528
(4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-b...)Show InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) | PDB
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| 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universitat de Barcelona
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells by liquid scintillation counting |
J Med Chem 52: 675-87 (2009)
Article DOI: 10.1021/jm8009469 BindingDB Entry DOI: 10.7270/Q2SN09V7 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50090528
(4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-b...)Show InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) | PDB
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| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense
Curated by ChEMBL
| Assay Description Binding affinity for human 5-hydroxytryptamine 6 receptor |
J Med Chem 48: 4216-9 (2005)
Checked by Author Article DOI: 10.1021/jm050247c BindingDB Entry DOI: 10.7270/Q2736SD0 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50090528
(4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-b...)Show InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) | PDB
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| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NPS Allelix Corp.
Curated by ChEMBL
| Assay Description Displacement of [3H]-LSD from human 5-hydroxytryptamine 6 receptor expressed in HEK 293 cells |
Bioorg Med Chem Lett 10: 1719-21 (2000)
BindingDB Entry DOI: 10.7270/Q2BP021W |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50090528
(4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-b...)Show InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) | PDB
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| Article PubMed
| 51.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by PDSP Ki Database
| |
Mol Pharmacol 64: 1295-308 (2003)
Article DOI: 10.1124/mol.64.6.1295 BindingDB Entry DOI: 10.7270/Q2BP01CZ |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50090528
(4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-b...)Show InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) | PDB
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| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-LaRoche
Curated by ChEMBL
| Assay Description Binding constant towards serotonin receptor subtype 5-hydroxytryptamine 6 receptor expressed in HeLa cells using [3H]LSD as radioligand |
J Med Chem 46: 1273-6 (2003)
Checked by Author Article DOI: 10.1021/jm021085c BindingDB Entry DOI: 10.7270/Q20G3MCZ |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50090528
(4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-b...)Show InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) | PDB
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| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Complutense de Madrid
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells |
J Med Chem 57: 7160-81 (2014)
Article DOI: 10.1021/jm5003952 BindingDB Entry DOI: 10.7270/Q2X92CZZ |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50090528
(4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-b...)Show InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) | PDB
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| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, PL 30-688 Kraków, Poland. Electronic address: dlazewska@cm-uj.krakow.pl.
Curated by ChEMBL
| Assay Description Binding affinity to human 5HT6R |
Eur J Med Chem 135: 117-124 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.033 BindingDB Entry DOI: 10.7270/Q2QN696C |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50090528
(4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-b...)Show InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) | PDB
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| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University
Curated by ChEMBL
| Assay Description Binding affinity towards human 5-hydroxytryptamine 6 receptor |
J Med Chem 46: 2795-812 (2003)
Article DOI: 10.1021/jm030030n BindingDB Entry DOI: 10.7270/Q2M0465F |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50090528
(4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-b...)Show InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) | PDB
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| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology
Curated by ChEMBL
| Assay Description Displacement of [3H]-LSD from human cloned 5HT6 receptor expressed in HEK293 cells |
Bioorg Med Chem Lett 18: 738-43 (2008)
Article DOI: 10.1016/j.bmcl.2007.11.045 BindingDB Entry DOI: 10.7270/Q2XK8F99 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50090528
(4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-b...)Show InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) | PDB
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| 55 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by ChEMBL
| Assay Description Displacement of [3H]LSD from human 5HT6 receptor expressed in HeLa cells |
Bioorg Med Chem Lett 19: 3214-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.04.108 BindingDB Entry DOI: 10.7270/Q2377927 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50090528
(4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-b...)Show InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) | PDB
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| | 58 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Virginia Commonwealth University
| Assay Description The h5-HT6 radioligand binding assays were performed as previously described. In brief, h5-HT6 cDNA was transiently expressed in HEK-293 cells using... |
Medicinal Chemistry Research 14: 1-18 (2005)
BindingDB Entry DOI: 10.7270/Q2NG4P78 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(MOUSE) | BDBM50090528
(4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-b...)Show InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) | PDB
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| >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by PDSP Ki Database
| |
Mol Pharmacol 64: 1295-308 (2003)
Article DOI: 10.1124/mol.64.6.1295 BindingDB Entry DOI: 10.7270/Q2BP01CZ |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50090528
(4-Amino-N-(2,6-bis-dimethylamino-pyrimidin-4-yl)-b...)Show InChI InChI=1S/C12H16N6O2S/c1-14-10-7-11(17-12(15-2)16-10)18-21(19,20)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H3,14,15,16,17,18) | PDB
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| n/a | n/a | 26.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Binding affinity towards 5-hydroxytryptamine 6 receptor using [3H]- LSD as radioligand |
J Med Chem 46: 4834-7 (2003)
Article DOI: 10.1021/jm034142q BindingDB Entry DOI: 10.7270/Q25T3JWV |
More data for this Ligand-Target Pair | |