BindingDB PrimarySearch

Found 9 hits Enz. Inhib. hit(s) with Target = '5-hydroxytryptamine receptor 7' and Ligand = 'BDBM50458526'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50458526 (CHEMBL4205349) Show SMILES CN(C)CCc1cccc(c1)-c1c(C)nn(C)c1C Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintil...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50458526 (CHEMBL4205349) Show SMILES CN(C)CCc1cccc(c1)-c1c(C)nn(C)c1C Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [3H] D-lysergic acid diethylamide from 5-HT7R (unknown origin) transfected in HEK293 cells incubated for 1.5 hrs by microbeta scintil...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50458526 (CHEMBL4205349) Show SMILES CN(C)CCc1cccc(c1)-c1c(C)nn(C)c1C Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Normandie Univ Curated by ChEMBL					Assay Description Antagonist activity at 5-HT7 receptor (unknown origin)				Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111705 BindingDB Entry DOI: 10.7270/Q2377D11
Normandie Univ Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50458526 (CHEMBL4205349) Show SMILES CN(C)CCc1cccc(c1)-c1c(C)nn(C)c1C Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Catania Curated by ChEMBL					Assay Description Binding affinity to 5-HT7 receptor (unknown origin)				J Med Chem 61: 8475-8503 (2018) Article DOI: 10.1021/acs.jmedchem.7b01898 BindingDB Entry DOI: 10.7270/Q2V98BPM
Universit£ di Catania Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50458526 (CHEMBL4205349) Show SMILES CN(C)CCc1cccc(c1)-c1c(C)nn(C)c1C Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00633 BindingDB Entry DOI: 10.7270/Q26M3BS8
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50458526 (CHEMBL4205349) Show SMILES CN(C)CCc1cccc(c1)-c1c(C)nn(C)c1C Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion g...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50458526 (CHEMBL4205349) Show SMILES CN(C)CCc1cccc(c1)-c1c(C)nn(C)c1C Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at 5-HT7R (unknown origin) transfected in HEK293 cells expressing tTA-dependent luciferase reporter and beta arrestin 2-TEV fusion g...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50458526 (CHEMBL4205349) Show SMILES CN(C)CCc1cccc(c1)-c1c(C)nn(C)c1C Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	83	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader ana...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50458526 (CHEMBL4205349) Show SMILES CN(C)CCc1cccc(c1)-c1c(C)nn(C)c1C Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	83	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human 5-HT7R transfected in HEK293 cells assessed as Gs-mediated cAMP accumulation incubated for 30 mins by microplate reader ana...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00110 BindingDB Entry DOI: 10.7270/Q2D50RTX
TBA					More data for this Ligand-Target Pair