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Found 1 hit Enz. Inhib. hit(s) with Target = '5-lipoxygenase' and Ligand = 'BDBM50043350'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-lipoxygenase


(Bos taurus)		BDBM50043350
PNG
(10-[3-(3,4-Dimethoxy-phenyl)-propionyl]-1,8-dihydr...)
Show SMILES COc1ccc(CCC(=O)C2c3cccc(O)c3C(=O)c3c(O)cccc23)cc1OC
Show InChI InChI=1S/C25H22O6/c1-30-20-12-10-14(13-21(20)31-2)9-11-19(28)22-15-5-3-7-17(26)23(15)25(29)24-16(22)6-4-8-18(24)27/h3-8,10,12-13,22,26-27H,9,11H2,1-2H3
PDB
MMDB

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n/an/a 1.70E+4n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).

J Med Chem 36: 4099-107 (1994)


BindingDB Entry DOI: 10.7270/Q2G44PC2
More data for this
Ligand-Target Pair