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Found 1 hit Enz. Inhib. hit(s) with Target = '5-lipoxygenase' and Ligand = 'BDBM50043365'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-lipoxygenase


(Bos taurus)		BDBM50043365
PNG
(1,8-Dihydroxy-10-[3-(3,4,5-trimethoxy-phenyl)-prop...)
Show SMILES COc1cc(CCC(=O)C2c3cccc(O)c3C(=O)c3c(O)cccc23)cc(OC)c1OC
Show InChI InChI=1S/C26H24O7/c1-31-20-12-14(13-21(32-2)26(20)33-3)10-11-19(29)22-15-6-4-8-17(27)23(15)25(30)24-16(22)7-5-9-18(24)28/h4-9,12-13,22,27-28H,10-11H2,1-3H3
PDB
MMDB

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PubMed
n/an/a 1.40E+4n/an/an/an/an/an/a



Universität Regensburg

Curated by ChEMBL


Assay Description
Inhibitory activity against 5-lipoxygenase (inhibition of 5-HETE and LTB4 biosynthesis) in bovine polymorphonuclear leukocytes (PMNL).

J Med Chem 36: 4099-107 (1994)


BindingDB Entry DOI: 10.7270/Q2G44PC2
More data for this
Ligand-Target Pair