Found 3 hits Enz. Inhib. hit(s) with Target = 'A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436' and Ligand = 'BDBM50475039' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50475039
(CHEMBL181025 | TP-103)Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Cc1ccc2ccccc2c1)C(=O)NC(Cc1ccc(O)cc1)C=O Show InChI InChI=1S/C35H37N3O6/c1-22(2)33(35(44)36-28(21-39)18-23-8-13-29(40)14-9-23)38-34(43)31(19-24-10-15-30(41)16-11-24)37-32(42)20-25-7-12-26-5-3-4-6-27(26)17-25/h3-17,21-22,28,31,33,40-41H,18-20H2,1-2H3,(H,36,44)(H,37,42)(H,38,43)/t28?,31-,33-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Numazu Bio-Medical Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory concentration to inhibit chymotrypsin-like activity of 20S proteasome prepared from human leukemia HL-60 cells was determined |
Bioorg Med Chem Lett 15: 1867-71 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.013
BindingDB Entry DOI: 10.7270/Q2CF9SVN |
More data for this
Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50475039
(CHEMBL181025 | TP-103)Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Cc1ccc2ccccc2c1)C(=O)NC(Cc1ccc(O)cc1)C=O Show InChI InChI=1S/C35H37N3O6/c1-22(2)33(35(44)36-28(21-39)18-23-8-13-29(40)14-9-23)38-34(43)31(19-24-10-15-30(41)16-11-24)37-32(42)20-25-7-12-26-5-3-4-6-27(26)17-25/h3-17,21-22,28,31,33,40-41H,18-20H2,1-2H3,(H,36,44)(H,37,42)(H,38,43)/t28?,31-,33-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Numazu Bio-Medical Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory concentration to inhibit trypsin-like activity of 20S proteasome from human leukemia HL-60 cells was determined |
Bioorg Med Chem Lett 15: 1867-71 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.013
BindingDB Entry DOI: 10.7270/Q2CF9SVN |
More data for this
Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50475039
(CHEMBL181025 | TP-103)Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)Cc1ccc2ccccc2c1)C(=O)NC(Cc1ccc(O)cc1)C=O Show InChI InChI=1S/C35H37N3O6/c1-22(2)33(35(44)36-28(21-39)18-23-8-13-29(40)14-9-23)38-34(43)31(19-24-10-15-30(41)16-11-24)37-32(42)20-25-7-12-26-5-3-4-6-27(26)17-25/h3-17,21-22,28,31,33,40-41H,18-20H2,1-2H3,(H,36,44)(H,37,42)(H,38,43)/t28?,31-,33-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Numazu Bio-Medical Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory concentration to inhibit the PGPH activity of 20S proteasome prepared from human leukemia HL-60 cells was determined |
Bioorg Med Chem Lett 15: 1867-71 (2005)
Article DOI: 10.1016/j.bmcl.2005.02.013
BindingDB Entry DOI: 10.7270/Q2CF9SVN |
More data for this
Ligand-Target Pair | |
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