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Found 1 hit Enz. Inhib. hit(s) with Target = 'ATP-dependent translocase ABCB1' and Ligand = 'BDBM50009054'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ATP-dependent translocase ABCB1


(Homo sapiens (Human))		BDBM50009054
PNG
(CHEMBL3237954)
Show SMILES COc1cc(CCc2ccccc2OCc2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC
Show InChI InChI=1S/C27H32O7/c1-28-22-13-18(14-23(29-2)26(22)32-5)11-12-20-9-7-8-10-21(20)34-17-19-15-24(30-3)27(33-6)25(16-19)31-4/h7-10,13-16H,11-12,17H2,1-6H3
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Article
PubMed
n/an/an/an/a 7.10n/an/an/an/a



Universit£ di Pisa

Curated by ChEMBL


Assay Description
Inhibition of P-glycoprotein (unknown origin) expressed in MDCK cells assessed as reduction of calcein-AM transport after 30 mins by fluorescence ass...

Eur J Med Chem 76: 558-66 (2014)


Article DOI: 10.1016/j.ejmech.2014.02.051
BindingDB Entry DOI: 10.7270/Q23F4R5W
More data for this
Ligand-Target Pair