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Found 1 hit Enz. Inhib. hit(s) with Target = 'ATP-dependent translocase ABCB1' and Ligand = 'BDBM50032253'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
ATP-dependent translocase ABCB1


(Homo sapiens (Human))		BDBM50032253
PNG
(CHEMBL3352981)
Show SMILES COc1cc2CCN(Cc3ccc(cc3)-c3ccc(F)cc3)Cc2cc1OC
Show InChI InChI=1S/C24H24FNO2/c1-27-23-13-20-11-12-26(16-21(20)14-24(23)28-2)15-17-3-5-18(6-4-17)19-7-9-22(25)10-8-19/h3-10,13-14H,11-12,15-16H2,1-2H3
PDB

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 4.90E+3n/an/an/an/a



Universit£ degli Studi di Bari"A. Moro"

Curated by ChEMBL


Assay Description
Inhibition of MDR1 (unknown origin) over-expressed in MDCK cells assessed as calcein accumulation incubated for 30 mins prior to Calcein-AM addition ...

J Med Chem 57: 9983-94 (2014)


Article DOI: 10.1021/jm501640e
BindingDB Entry DOI: 10.7270/Q2K9394N
More data for this
Ligand-Target Pair