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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet  | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 880 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Kansas Curated by ChEMBL | Assay Description TP_TRANSPORTER: transepithelial transport of digoxin (basal to apical) in Caco-2 cells | Pharm Res 20: 161-8 (2003) Article DOI: 10.1023/a:1022359300826 BindingDB Entry DOI: 10.7270/Q2BP05N6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Hong Kong Polytechnic University Curated by ChEMBL | Assay Description Competitive inhibition of P-gp overexpressed in human MDA435/LCC6MDR cells assessed as accumulation of doxorubicin by Lineweaver-Burk plot analysis | J Med Chem 55: 1999-2014 (2012) Article DOI: 10.1021/jm201121b BindingDB Entry DOI: 10.7270/Q2JW8HRN | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The Hong Kong Polytechnic University Curated by ChEMBL | Assay Description Competitive inhibition of P-gp overexpressed in human MDA435/LCC6MDR cells assessed as accumulation of doxorubicin by Dixon plot analysis | J Med Chem 55: 1999-2014 (2012) Article DOI: 10.1021/jm201121b BindingDB Entry DOI: 10.7270/Q2JW8HRN | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Kansas Curated by ChEMBL | Assay Description TP_TRANSPORTER: inhibition of Taxol transepithelial transport (basal to apical) in Caco-2 cells | Pharm Res 18: 171-6 (2001) Article DOI: 10.1023/a:1011076217118 BindingDB Entry DOI: 10.7270/Q2N300T9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Reversal of P-glycoprotein mediated multidrug resistance in human KBV cells assessed as reversal of resistance to vincristine-induced cytotoxicity by... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.113107 BindingDB Entry DOI: 10.7270/Q2SX6HZ3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 2.5 uM measu... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112422 BindingDB Entry DOI: 10.7270/Q22Z1974 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Reversal of P-glycoprotein mediated multidrug resistance in human KBV cells assessed as reversal of resistance to vincristine-induced cytotoxicity by... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.113107 BindingDB Entry DOI: 10.7270/Q2SX6HZ3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University) Curated by ChEMBL | Assay Description Reversal of P-gp-mediated drug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50... | Eur J Med Chem 161: 364-377 (2019) Article DOI: 10.1016/j.ejmech.2018.10.033 BindingDB Entry DOI: 10.7270/Q2D50R79 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to vincristine-induced cytotoxicity... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.113107 BindingDB Entry DOI: 10.7270/Q2SX6HZ3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 2.5 uM measured... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112422 BindingDB Entry DOI: 10.7270/Q22Z1974 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 7.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ABCB1 in multidrug-resistant human KB-C2 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by mea... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01741 BindingDB Entry DOI: 10.7270/Q20K2D5F | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to paclitaxel-induced cytotoxicity ... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.113107 BindingDB Entry DOI: 10.7270/Q2SX6HZ3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 2.5 uM measured a... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112422 BindingDB Entry DOI: 10.7270/Q22Z1974 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 2.5 uM measure... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112422 BindingDB Entry DOI: 10.7270/Q22Z1974 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to vincristine-induced cytotoxicity... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.113107 BindingDB Entry DOI: 10.7270/Q2SX6HZ3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ABCB1 (unknown origin) expressed in HEK293 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity by m... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01741 BindingDB Entry DOI: 10.7270/Q20K2D5F | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Reversal of P-glycoprotein mediated multidrug resistance in human MCF-7T cells assessed as reversal of resistance to paclitaxel-induced cytotoxicity ... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.113107 BindingDB Entry DOI: 10.7270/Q2SX6HZ3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Yantai University Curated by ChEMBL | Assay Description Reversal of P-gp-mediated multidrug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel... | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111668 BindingDB Entry DOI: 10.7270/Q2QC06W2 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Reversal of P-glycoprotein mediated multidrug resistance in human KBV cells assessed as reversal of resistance to paclitaxel-induced cytotoxicity by ... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.113107 BindingDB Entry DOI: 10.7270/Q2SX6HZ3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Universities of Shandong Curated by ChEMBL | Assay Description Reversal of P-gp-mediated multidrug resistance in human KBV cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel... | Eur J Med Chem 161: 118-130 (2019) Article DOI: 10.1016/j.ejmech.2018.10.038 BindingDB Entry DOI: 10.7270/Q22V2KD1 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Firenze Curated by ChEMBL | Assay Description Modulatory activity at P-gp assessed as doxorubicin IC50 in human K562 cells at 3 uM after 72 hrs by MTT assay (Rvb doxorubicin alone IC50 = 0.023 +/... | Eur J Med Chem 87: 398-412 (2014) Article DOI: 10.1016/j.ejmech.2014.09.084 BindingDB Entry DOI: 10.7270/Q2H41VF6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Yantai University Curated by ChEMBL | Assay Description Reversal of P-gp-mediated multidrug resistance in human KBV cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristi... | Eur J Med Chem 182: (2019) Article DOI: 10.1016/j.ejmech.2019.111668 BindingDB Entry DOI: 10.7270/Q2QC06W2 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Reversal of P-glycoprotein mediated multidrug resistance in human KBV cells assessed as reversal of resistance to paclitaxel-induced cytotoxicity by ... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.113107 BindingDB Entry DOI: 10.7270/Q2SX6HZ3 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
The Hong Kong Polytechnic University Curated by ChEMBL | Assay Description Modulation of P-gp (unknown origin) transfected in human MDA435/LCC6MDR cells assessed as reversible of paclitaxel resistance measured as IC50 for pa... | J Med Chem 58: 4529-49 (2015) Article DOI: 10.1021/acs.jmedchem.5b00085 BindingDB Entry DOI: 10.7270/Q2N29ZP5 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-glycoprotein in human LCC6MDR cells assessed as reversal fold by measuring reduction in paclitaxel by measuring paclitaxel IC50 at 1 ... | Citation and Details Article DOI: 10.1016/j.ejmech.2021.113795 BindingDB Entry DOI: 10.7270/Q2GF0ZDD | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ABCB1 in FLp-In-293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 2.5 uM measured... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112422 BindingDB Entry DOI: 10.7270/Q22Z1974 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 2.5 uM measured... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112422 BindingDB Entry DOI: 10.7270/Q22Z1974 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ABCB1 in human HeLa S3 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 2.5 uM measu... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112422 BindingDB Entry DOI: 10.7270/Q22Z1974 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 195 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincristine IC50 at 2.5 uM measur... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112422 BindingDB Entry DOI: 10.7270/Q22Z1974 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ABCB1 in multidrug-resistant human SW620/Ad300 cells assessed as increase in reversal of resistance to paclitaxel-induced cytotoxicity ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01741 BindingDB Entry DOI: 10.7270/Q20K2D5F | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 412 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitax... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112422 BindingDB Entry DOI: 10.7270/Q22Z1974 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 456 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of vincristine-induced cytotoxicity by measuring vincris... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112422 BindingDB Entry DOI: 10.7270/Q22Z1974 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"Aldo Moro" Curated by ChEMBL | Assay Description Inhibition of human MDR1 expressed in MDCK cells assessed as calcein AM accumulation after 30 mins by fluorescence assay | J Med Chem 55: 424-36 (2012) Article DOI: 10.1021/jm201305y BindingDB Entry DOI: 10.7270/Q2HD7W35 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 522 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human full-length ABCB1 expressed in FLp-In-293 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorub... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112422 BindingDB Entry DOI: 10.7270/Q22Z1974 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 575 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Vienna Curated by ChEMBL | Assay Description Inhibition of P-glycoprotein-mediated daunorubicin efflux from human CCRF-CEM/VCR1000 cells after 240 secs by FACS flow cytometric analysis | J Med Chem 55: 3261-73 (2012) Article DOI: 10.1021/jm201705f BindingDB Entry DOI: 10.7270/Q2ZP48ZK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of P-glycoprotein overexpressed in human SW620/AD300 cells assessed as reversal of doxorubicin resistance by measuring doxorubicin IC50 at... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01989 BindingDB Entry DOI: 10.7270/Q2QZ2FV4 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 708 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ABCB1 in human KB-VIN cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring doxorubicin IC50 at 2.5 uM measur... | Citation and Details Article DOI: 10.1016/j.ejmech.2020.112422 BindingDB Entry DOI: 10.7270/Q22Z1974 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 710 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jnatprod.1c00821 BindingDB Entry DOI: 10.7270/Q2XW4PVZ | ||||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 740 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Firenze Curated by ChEMBL | Assay Description Modulatory activity at P-gp assessed as doxorubicin IC50 in human K562/DOX cells at 3 uM after 72 hrs by MTT assay (Rvb doxorubicin alone IC50 = 2.00... | Eur J Med Chem 87: 398-412 (2014) Article DOI: 10.1016/j.ejmech.2014.09.084 BindingDB Entry DOI: 10.7270/Q2H41VF6 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 810 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Queensland Curated by ChEMBL | Assay Description Reversal of P-gp mediated multidrug resistance in human SW620/AD300 cells assessed as potentiation of doxorubicin-induced antiproliferative activity ... | J Nat Prod 83: 497-504 (2020) Article DOI: 10.1021/acs.jnatprod.9b01181 BindingDB Entry DOI: 10.7270/Q23F4T65 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue University Curated by ChEMBL | Assay Description Inhibition of P-gp in human 12D7-MDR cells using calcein-AM as substrate | J Med Chem 63: 2131-2138 (2020) Article DOI: 10.1021/acs.jmedchem.9b00779 BindingDB Entry DOI: 10.7270/Q28P640X | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Degli Studi di Bari "Aldo Moro" Curated by ChEMBL | Assay Description Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as reduction in calcein-AM efflux preincubated for 30 mins followed by calcein-A... | Eur J Med Chem 161: 433-444 (2019) Article DOI: 10.1016/j.ejmech.2018.10.043 BindingDB Entry DOI: 10.7270/Q24M97VK | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University Curated by ChEMBL | Assay Description Reversal of P-gp mediated multidrug resistance in human HepG2/DOX cells assessed as doxorubicin IC50 at 10 uM measured within 48 hrs by MTT assay (Rv... | Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111726 BindingDB Entry DOI: 10.7270/Q20R9SNN | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Firenze Curated by ChEMBL | Assay Description Inhibition of P-glycoprotein in human doxorubicin-resistant K562 cells assessed as half maximal increase of pirarubicin accumulation by spectrofluoro... | Bioorg Med Chem 21: 456-65 (2013) Article DOI: 10.1016/j.bmc.2012.11.019 BindingDB Entry DOI: 10.7270/Q2ST7SQM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Research Institute of Chemical Technology Curated by ChEMBL | Assay Description TP_TRANSPORTER: drug resistance (paclitaxel) in HCT15/CL02 cells | Anticancer Drugs 14: 175-81 (2003) Article DOI: 10.1097/01.cad.0000054526.51553.e8 BindingDB Entry DOI: 10.7270/Q25H7HJC | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Medical Sciences & Peking Union Medical College Curated by ChEMBL | Assay Description Reversal of Pgp-mediated DOX resistance in human SW620/AD300 cells assessed as potentiation of DOX-induced cytotoxicity by measuring DOX IC50 at 1 uM... | J Med Chem 63: 5458-5476 (2020) Article DOI: 10.1021/acs.jmedchem.0c00337 BindingDB Entry DOI: 10.7270/Q2ST7TCJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | PubMed | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Research Institute Curated by ChEMBL | Assay Description Evaluated for cytotoxicity using P388/VMDRC.04 cells (a subline of P388 murine leukemia cells expressing human recombinant human P-glycoprotein) in t... | Bioorg Med Chem Lett 9: 1541-6 (1999) BindingDB Entry DOI: 10.7270/Q22R3ST7 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University Curated by ChEMBL | Assay Description Reversal of P-gp mediated multidrug resistance in human MCF7/ADM cells assessed as doxorubicin IC50 at 10 uM measured within 48 hrs by MTT assay (Rvb... | Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111726 BindingDB Entry DOI: 10.7270/Q20R9SNN | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Jinan University Curated by ChEMBL | Assay Description Reversal of P-gp mediated multidrug resistance in human HepG2/DOX cells assessed as doxorubicin IC50 at 5 uM measured within 48 hrs by MTT assay (Rvb... | Eur J Med Chem 183: (2019) Article DOI: 10.1016/j.ejmech.2019.111726 BindingDB Entry DOI: 10.7270/Q20R9SNN | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| ATP-dependent translocase ABCB1 (Homo sapiens (Human)) | BDBM81939 (CAS_52-53-9 | NSC_62969 | VERAPAMIL) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of P-gp in doxorubicin-resistant human MCF7/ADR cells assessed as reversal of doxorubicin resistance by measuring doxorubicin IC50 incubat... | J Nat Prod 82: 724-734 (2019) Article DOI: 10.1021/acs.jnatprod.8b00507 BindingDB Entry DOI: 10.7270/Q2DR3002 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
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