Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM50204280 (CHEMBL3987135 | US9573961, Example 15) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 50 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu... | US Patent US9573961 (2017) BindingDB Entry DOI: 10.7270/Q241704N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM50204280 (CHEMBL3987135 | US9573961, Example 15) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 57 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center Curated by ChEMBL | Assay Description Inhibition of human ROMK1 expressed in HEK293 cells by Tl+ flux assay | J Med Chem 62: 8682-8694 (2019) Article DOI: 10.1021/acs.jmedchem.8b01891 BindingDB Entry DOI: 10.7270/Q2GH9N7J | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human)) | BDBM50204280 (CHEMBL3987135 | US9573961, Example 15) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibition of human ROMK expressed in CHO cells after 6 mins at -70 mV holding potential by electrophysiology method | Bioorg Med Chem Lett 26: 5695-5702 (2016) Article DOI: 10.1016/j.bmcl.2016.10.064 BindingDB Entry DOI: 10.7270/Q2F191PS | |||||||||||
More data for this Ligand-Target Pair |