Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ATR-interacting protein/DNA topoisomerase 2-binding protein 1/Dual specificity protein kinase CLK2/Serine/threonine-protein kinase ATR (Homo sapiens (Human)) | BDBM411840 (US10392391, Compound I-N-275 | US10787452, Compoun...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | UniChem | US Patent | <20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Assays were carried out at 25° C. in the presence of 4 nM full-length ATR, 40 nM full-length ATRIP, 40 nM full-length CLK2 and 600 nM TopBP1(A891-S11... | Citation and Details BindingDB Entry DOI: 10.7270/Q2639SW3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATR-interacting protein/DNA topoisomerase 2-binding protein 1/Dual specificity protein kinase CLK2/Serine/threonine-protein kinase ATR (Homo sapiens (Human)) | BDBM411840 (US10392391, Compound I-N-275 | US10787452, Compoun...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | UniChem | US Patent | <200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Table 7: Compounds were screened for their ability to inhibit ATR kinase, in the presence of partner proteins ATRIP, CLK2 and TopBP1, using a radioac... | Citation and Details BindingDB Entry DOI: 10.7270/Q2MP56GR | |||||||||||
More data for this Ligand-Target Pair |