Found 82 hits Enz. Inhib. hit(s) with Target = 'Adenosine receptor A1' and Ligand = 'BDBM10847' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
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| DrugBank Article PubMed
| 0.600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CV Therapeutics, Inc.
Curated by ChEMBL
| Assay Description Binding affinity for adenosine A1 receptor by using as [3H]-CPX iradioligand n membranes from Chinese hamster ovary cells |
Bioorg Med Chem Lett 15: 609-12 (2005)
Article DOI: 10.1016/j.bmcl.2004.11.044 BindingDB Entry DOI: 10.7270/Q29K49QX |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merrell Dow Research Institute
Curated by ChEMBL
| Assay Description Inhibition of [3H]-CHA binding to rat brain membrane Adenosine A1 receptor |
J Med Chem 33: 3127-30 (1991)
BindingDB Entry DOI: 10.7270/Q2ZC83GN |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(BOVINE) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
Reactome pathway KEGG
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| Article PubMed
| 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Binding affinity against adenosine A1 receptor in bovine brain membranes by [3H]CHA displacement. |
J Med Chem 47: 3580-90 (2004)
Article DOI: 10.1021/jm031136l BindingDB Entry DOI: 10.7270/Q2CV4JHH |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(BOVINE) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita' di Firenze
Curated by ChEMBL
| Assay Description Binding affinity towards adenosine A1 receptor of bovine brain membrane using [3H]-CHA at 20 uM |
J Med Chem 43: 1158-64 (2000)
BindingDB Entry DOI: 10.7270/Q2QR4WBG |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(BOVINE) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| Article PubMed
| 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Heidelberg
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 336: 204-10 (1987)
Article DOI: 10.1007/bf00165806 BindingDB Entry DOI: 10.7270/Q26H4FXN |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(BOVINE) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| Article PubMed
| 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Firenze
Curated by ChEMBL
| Assay Description Displacement of [3H]CHA from adenosine A1 receptor in bovine cerebral cortical membranes |
J Med Chem 48: 7932-45 (2005)
Article DOI: 10.1021/jm0504149 BindingDB Entry DOI: 10.7270/Q20V8CCR |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(BOVINE) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| Article PubMed
| 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Firenze
Curated by ChEMBL
| Assay Description Displacement of [3H]DPCPX from adenosine A1 receptor in bovine brain membranes |
J Med Chem 49: 3916-25 (2006)
Article DOI: 10.1021/jm060373w BindingDB Entry DOI: 10.7270/Q25H7FW1 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(BOVINE) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| Article PubMed
| 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita' di Firenze
Curated by ChEMBL
| Assay Description Displacement of [125I]DPCPX from adenosine A1 receptor in bovine brain membrane |
Bioorg Med Chem 16: 6086-102 (2008)
Article DOI: 10.1016/j.bmc.2008.04.039 BindingDB Entry DOI: 10.7270/Q2TQ61BG |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(BOVINE) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| Article PubMed
| 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita di Firenze
Curated by ChEMBL
| Assay Description Displacement of [3H]DPCPX from bovine brain cortical membrane adenosine A1 receptor |
J Med Chem 52: 2407-19 (2009)
Article DOI: 10.1021/jm8014876 BindingDB Entry DOI: 10.7270/Q2X63MVV |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(BOVINE) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita' di Firenze
Curated by ChEMBL
| Assay Description Displacement of [3H]-CHA from adenosine A1 receptor in bovine brain membranes |
J Med Chem 43: 3118-24 (2000)
BindingDB Entry DOI: 10.7270/Q28S4P52 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Oryctolagus cuniculus (Rabbit)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
KEGG
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| Article PubMed
| 4.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Heidelberg
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 343: 196-201 (1991)
Article DOI: 10.1007/bf00168610 BindingDB Entry DOI: 10.7270/Q22V2DMN |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(BOVINE) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| Article PubMed
| 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 330: 212-21 (1985)
Article DOI: 10.1007/bf00572436 BindingDB Entry DOI: 10.7270/Q2RB7334 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| Article PubMed
| 5.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Heidelberg
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 343: 196-201 (1991)
Article DOI: 10.1007/bf00168610 BindingDB Entry DOI: 10.7270/Q22V2DMN |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(GUINEA PIG) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| Article PubMed
| 5.98E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Heidelberg
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 343: 196-201 (1991)
Article DOI: 10.1007/bf00168610 BindingDB Entry DOI: 10.7270/Q22V2DMN |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(BOVINE) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Center for Bio-Pharmaceutical Sciences
Curated by ChEMBL
| Assay Description Displacement of [3H]CPX from adenosine A1 receptor of calf brain cortical membrane |
J Med Chem 34: 1202-6 (1991)
BindingDB Entry DOI: 10.7270/Q2W37WX7 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| DrugBank PubMed
| 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia
Curated by PDSP Ki Database
| |
Mol Pharmacol 56: 705-13 (1999)
BindingDB Entry DOI: 10.7270/Q2M9077B |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| DrugBank Article PubMed
| 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Firenze
Curated by ChEMBL
| Assay Description Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells |
J Med Chem 49: 3916-25 (2006)
Article DOI: 10.1021/jm060373w BindingDB Entry DOI: 10.7270/Q25H7FW1 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| DrugBank Article PubMed
| 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Binding affinity to human adenosine A1 receptor |
J Med Chem 52: 3994-4006 (2009)
Article DOI: 10.1021/jm900413e BindingDB Entry DOI: 10.7270/Q24J0G1M |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| DrugBank Article PubMed
| 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Firenze
Curated by ChEMBL
| Assay Description Binding affinity against human adenosine A1 receptor expressed in CHO cells using [3H]CHA |
J Med Chem 47: 3580-90 (2004)
Article DOI: 10.1021/jm031136l BindingDB Entry DOI: 10.7270/Q2CV4JHH |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| DrugBank Article PubMed
| 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita di Firenze
Curated by ChEMBL
| Assay Description Displacement of [3H]DPCPX from human cloned adenosine A1 receptor expressed in CHO cells |
J Med Chem 52: 2407-19 (2009)
Article DOI: 10.1021/jm8014876 BindingDB Entry DOI: 10.7270/Q2X63MVV |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| DrugBank Article PubMed
| 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universita' di Firenze
Curated by ChEMBL
| Assay Description Displacement of [125I]DPCPX from human cloned adenosine A1 receptor expressed in CHO cells |
Bioorg Med Chem 16: 6086-102 (2008)
Article DOI: 10.1016/j.bmc.2008.04.039 BindingDB Entry DOI: 10.7270/Q2TQ61BG |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| DrugBank Article PubMed
| 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Firenze
Curated by ChEMBL
| Assay Description Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cells |
J Med Chem 50: 4061-74 (2007)
Article DOI: 10.1021/jm070123v BindingDB Entry DOI: 10.7270/Q2JM29BR |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| DrugBank Article PubMed
| 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi di Firenze
Curated by ChEMBL
| Assay Description Displacement of [3H]CHA from cloned human adenosine A1 receptor expressed in CHO cells |
J Med Chem 48: 7932-45 (2005)
Article DOI: 10.1021/jm0504149 BindingDB Entry DOI: 10.7270/Q20V8CCR |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(BOVINE) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| Article PubMed
| 6.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Heidelberg
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 343: 196-201 (1991)
Article DOI: 10.1007/bf00168610 BindingDB Entry DOI: 10.7270/Q22V2DMN |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| 6.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113907 BindingDB Entry DOI: 10.7270/Q20K2DJC |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| 6.77E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bonn
Curated by ChEMBL
| Assay Description Displacement of [3H]CCPA from human adenosine A1 receptor expressed in CHO cells |
Bioorg Med Chem 18: 2195-203 (2010)
Article DOI: 10.1016/j.bmc.2010.01.072 BindingDB Entry DOI: 10.7270/Q2BZ670J |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| 6.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes & Digestive & Kidney Diseases
Curated by ChEMBL
| Assay Description Binding affinity of specific [3H]-R-PIA binding to rat Adenosine A1 receptor in HEK-293 cells |
J Med Chem 45: 2131-8 (2002)
BindingDB Entry DOI: 10.7270/Q2V1243G |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| 6.92E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CV Therapeutics Inc.
Curated by ChEMBL
| Assay Description Displacement of [3H]CPX from human adenosine A3 receptor expressed in CHO cells |
J Med Chem 49: 3682-92 (2006)
Article DOI: 10.1021/jm051268+ BindingDB Entry DOI: 10.7270/Q21V5DMG |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(GUINEA PIG) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| Article PubMed
| 7.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Heidelberg
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 343: 196-201 (1991)
Article DOI: 10.1007/bf00168610 BindingDB Entry DOI: 10.7270/Q22V2DMN |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| 7.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merrell Dow Research Institute
Curated by ChEMBL
| Assay Description In vitro binding affinity to Adenosine A1 receptor of rat cerebral cortical membranes using 1 nM [3H]-PIA |
J Med Chem 31: 2034-9 (1988)
BindingDB Entry DOI: 10.7270/Q2988614 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 8.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK
Curated by ChEMBL
| Assay Description Inhibition of binding of 1 nM [3H]N-6-(phenylisopropyl)adenosine to adenosine A1 receptor in rat cortical membranes |
J Med Chem 32: 1873-9 (1989)
BindingDB Entry DOI: 10.7270/Q2708213 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 8.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description Binding affinity towards adenosine A1 receptor in rat whole brain membranes using N6-[3H]cyclohexyladenosine |
J Med Chem 35: 3066-75 (1992)
BindingDB Entry DOI: 10.7270/Q2DN45PF |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| 8.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of N6-[3H]cyclohexyladenosine binding to adenosine A1 receptor from whole brain membranes |
J Med Chem 35: 2342-5 (1992)
BindingDB Entry DOI: 10.7270/Q2T43S20 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| 8.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description Binding affinity towards adenosine A1 receptor in rat whole brain membranes using N6-[3H]cyclohexyladenosine |
J Med Chem 35: 3066-75 (1992)
BindingDB Entry DOI: 10.7270/Q2DN45PF |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 8.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description Tested for binding affinity against Adenosine A1 receptor from rat forebrain membranes, using N6-[3H]- cyclohexyladenosine as radioligand |
J Med Chem 36: 2508-18 (1993)
BindingDB Entry DOI: 10.7270/Q2GX4C5K |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 8.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyowa Hakko Kogyo Co., Ltd.
Curated by ChEMBL
| Assay Description Binding affinity against Adenosine A1 receptor using N6-[3H]-cyclohexyladenosinene in rat whole brain membranes |
J Med Chem 35: 924-30 (1992)
BindingDB Entry DOI: 10.7270/Q2NS0VJZ |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 8.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert/Parke-Davis Pharmaceutical Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 29: 331-46 (1986)
BindingDB Entry DOI: 10.7270/Q2MK6BDV |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Institute of Diabetes
Curated by ChEMBL
| Assay Description Displacement of [3H]-PIA from adenosine A1 receptors of rat brain membrane |
J Med Chem 37: 3373-82 (1994)
BindingDB Entry DOI: 10.7270/Q28914WW |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of South Florida
Curated by ChEMBL
| Assay Description Binding affinity against Adenosine A1 receptor in rat brain membrane, using [3H]-N6-cyclohexyladenosine as the radioligand |
J Med Chem 32: 2247-54 (1989)
BindingDB Entry DOI: 10.7270/Q2H70DTD |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| Article PubMed
| 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute
Curated by ChEMBL
| Assay Description Binding affinity to rat adenosine A1 receptor |
J Med Chem 52: 3994-4006 (2009)
Article DOI: 10.1021/jm900413e BindingDB Entry DOI: 10.7270/Q24J0G1M |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NIDDK
Curated by ChEMBL
| Assay Description Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand |
J Med Chem 35: 407-22 (1992)
BindingDB Entry DOI: 10.7270/Q2Z89D1W |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Center for Bio-Pharmaceutical Sciences
Curated by ChEMBL
| Assay Description Inhibition of [3H]-CHA binding to Adenosine A1 receptor in rat brain membranes |
J Med Chem 33: 1708-13 (1990)
BindingDB Entry DOI: 10.7270/Q2CZ3643 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(BOVINE) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Camerino
Curated by ChEMBL
| Assay Description Affinity to A1 adenosine receptor was measured by the displacement of [3H]-PIA in bovine brain cortical membrane |
J Med Chem 37: 2970-5 (1994)
BindingDB Entry DOI: 10.7270/Q23777ST |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Homo sapiens (Human)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| DrugBank PubMed
| 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Binding affinity to adenosine A1 receptor |
J Nat Prod 63: 315-7 (2000)
BindingDB Entry DOI: 10.7270/Q2SB46M8 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| Article PubMed
| 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of rat recombinant adenosine A1 receptor |
J Med Chem 57: 3623-50 (2014)
Article DOI: 10.1021/jm4011669 BindingDB Entry DOI: 10.7270/Q28P621J |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 9.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Center for Bio-Pharmaceutical Sciences
Curated by ChEMBL
| Assay Description Displacement of [3H]CPX from adenosine A1 receptor of rat brain cortical membrane |
J Med Chem 34: 1202-6 (1991)
BindingDB Entry DOI: 10.7270/Q2W37WX7 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| Article PubMed
| 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universität Heidelberg
Curated by PDSP Ki Database
| |
Naunyn Schmiedebergs Arch Pharmacol 336: 204-10 (1987)
Article DOI: 10.1007/bf00165806 BindingDB Entry DOI: 10.7270/Q26H4FXN |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(GUINEA PIG) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Affinity against adenosine A1 receptor in the brain membranes by the displacement of [3H]-CPX. |
J Med Chem 35: 4039-44 (1992)
BindingDB Entry DOI: 10.7270/Q2CF9P23 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(GUINEA PIG) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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| PubMed
| 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Binding affinity against adenosine A1 receptor of cerebral cortex using [3H]-CPX as a radioligand |
J Med Chem 36: 1380-6 (1993)
BindingDB Entry DOI: 10.7270/Q23B5Z65 |
More data for this Ligand-Target Pair | |
Adenosine receptor A1
(Rattus norvegicus (rat)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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TBA
Curated by PDSP Ki Database
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Naunyn Schmiedebergs Arch Pharmacol 330: 212-21 (1985)
Article DOI: 10.1007/bf00572436 BindingDB Entry DOI: 10.7270/Q2RB7334 |
More data for this Ligand-Target Pair | |