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Found 2 hits Enz. Inhib. hit(s) with Target = 'Alkaline phosphatase, tissue-nonspecific isozyme' and Ligand = 'BDBM275079'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))		BDBM275079
PNG
(US10221195, Example 21 | US9879032, Example 21)
Show SMILES COc1ccc(F)cc1S(=O)(=O)Nc1cnc2OC[C@@H](C)N(C)C(=O)c2c1 |r|
Show InChI InChI=1S/C17H18FN3O5S/c1-10-9-26-16-13(17(22)21(10)2)7-12(8-19-16)20-27(23,24)15-6-11(18)4-5-14(15)25-3/h4-8,10,20H,9H2,1-3H3/t10-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 46n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...

US Patent US10221195 (2019)


BindingDB Entry DOI: 10.7270/Q2QZ2D83
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))		BDBM275079
PNG
(US10221195, Example 21 | US9879032, Example 21)
Show SMILES COc1ccc(F)cc1S(=O)(=O)Nc1cnc2OC[C@@H](C)N(C)C(=O)c2c1 |r|
Show InChI InChI=1S/C17H18FN3O5S/c1-10-9-26-16-13(17(22)21(10)2)7-12(8-19-16)20-27(23,24)15-6-11(18)4-5-14(15)25-3/h4-8,10,20H,9H2,1-3H3/t10-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 46n/an/an/an/an/a25



Daiichi Sankyo Company, Limited; Sandford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS 1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (In...

US Patent US9879032 (2018)


BindingDB Entry DOI: 10.7270/Q2F76FKB
More data for this
Ligand-Target Pair