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Found 2 hits Enz. Inhib. hit(s) with Target = 'Alkaline phosphatase, tissue-nonspecific isozyme' and Ligand = 'BDBM275095'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM275095
PNG
(US10221195, Example 37 | US9879032, Example 37)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OCCN(c3ccccc3)C(=O)c2c1
Show InChI InChI=1S/C21H18ClN3O5S/c1-29-18-8-7-14(22)11-19(18)31(27,28)24-15-12-17-20(23-13-15)30-10-9-25(21(17)26)16-5-3-2-4-6-16/h2-8,11-13,24H,9-10H2,1H3
PDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 43.4n/an/an/an/an/an/a



Daiichi Sankyo Company, Limited; Sanford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (Inv...


US Patent US10221195 (2019)


BindingDB Entry DOI: 10.7270/Q2QZ2D83
More data for this
Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme


(Homo sapiens (Human))
BDBM275095
PNG
(US10221195, Example 37 | US9879032, Example 37)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)Nc1cnc2OCCN(c3ccccc3)C(=O)c2c1
Show InChI InChI=1S/C21H18ClN3O5S/c1-29-18-8-7-14(22)11-19(18)31(27,28)24-15-12-17-20(23-13-15)30-10-9-25(21(17)26)16-5-3-2-4-6-16/h2-8,11-13,24H,9-10H2,1H3
PDB

KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 43.4n/an/an/an/an/a25



Daiichi Sankyo Company, Limited; Sandford Burnham Prebys Medical Discovery Institute

US Patent


Assay Description
COS 1 cells (DS Pharma Biomedical Co., Ltd.) were transfected with human TNAP (OriGene Technologies, Inc.) using Lipofectamine LTX & Plus reagent (In...


US Patent US9879032 (2018)


BindingDB Entry DOI: 10.7270/Q2F76FKB
More data for this
Ligand-Target Pair