BindingDB PrimarySearch

Found 13 hits Enz. Inhib. hit(s) with Target = 'Alkaline phosphatase, tissue-nonspecific isozyme' and Ligand = 'BDBM50241179'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alkaline phosphatase, tissue-nonspecific isozyme (Bos taurus (Cattle))	BDBM50241179 ((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...) Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1 \|r,c:5\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	1.81E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Forman Christian College (A Chartered University) Curated by ChEMBL					Assay Description Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...				Bioorg Med Chem 23: 2435-44 (2015) Article DOI: 10.1016/j.bmc.2015.03.054 BindingDB Entry DOI: 10.7270/Q2WW7KC8
					More data for this Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme (Homo sapiens (Human))	BDBM50241179 ((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...) Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1 \|r,c:5\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	9.8	n/a
Universit£ de Lyon Curated by ChEMBL					Assay Description Inhibition of human tissue non-specific alkaline phosphatase at pH 9.8				Bioorg Med Chem 17: 7290-300 (2009) Article DOI: 10.1016/j.bmc.2009.08.048 BindingDB Entry DOI: 10.7270/Q2VM4CB4
Universit£ de Lyon Curated by ChEMBL					More data for this Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme (Homo sapiens (Human))	BDBM50241179 ((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...) Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1 \|r,c:5\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute for Medical Research Curated by ChEMBL					Assay Description Inhibition of TNSALP (unknown origin)				Bioorg Med Chem Lett 19: 222-5 (2008) Article DOI: 10.1016/j.bmcl.2008.10.107 BindingDB Entry DOI: 10.7270/Q2CR5T64
Institute for Medical Research Curated by ChEMBL					More data for this Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme (Homo sapiens (Human))	BDBM50241179 ((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...) Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1 \|r,c:5\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	9.30E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Claude Bernard-Lyon 1 Curated by ChEMBL					Assay Description Inhibition of recombinant TNAP				Bioorg Med Chem Lett 21: 2297-301 (2011) Article DOI: 10.1016/j.bmcl.2011.02.089 BindingDB Entry DOI: 10.7270/Q2V988CR
Universit£ Claude Bernard-Lyon 1 Curated by ChEMBL					More data for this Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme (Homo sapiens (Human))	BDBM50241179 ((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...) Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1 \|r,c:5\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Human BioMolecular Research Institute Curated by ChEMBL					Assay Description Inhibition of TNAP by analogous luminescence assay				Bioorg Med Chem 18: 573-9 (2010) Article DOI: 10.1016/j.bmc.2009.12.012 BindingDB Entry DOI: 10.7270/Q24T6JHR
Human BioMolecular Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme (Homo sapiens (Human))	BDBM50241179 ((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...) Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1 \|r,c:5\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.92E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Rostock Curated by ChEMBL					Assay Description Inhibition of human TNAP expressed in COS7 cells preincubated for 5 to 7 mins followed by CDP-star substrate addition measured after 15 to 20 mins by...				Eur J Med Chem 144: 116-127 (2018) Article DOI: 10.1016/j.ejmech.2017.11.068 BindingDB Entry DOI: 10.7270/Q2W66PDP
Universit£t Rostock Curated by ChEMBL					More data for this Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme (Bos taurus (Cattle))	BDBM50241179 ((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...) Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1 \|r,c:5\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.92E+4	n/a	n/a	n/a	n/a	9.8	37
Quaid-I-Azam University					Assay Description The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...				Chem Biol Drug Des 89: 365-370 (2017) Article DOI: 10.1111/cbdd.12861 BindingDB Entry DOI: 10.7270/Q2F47N10
Quaid-I-Azam University					More data for this Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme (Bos taurus (Cattle))	BDBM50241179 ((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...) Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1 \|r,c:5\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.92E+4	n/a	n/a	n/a	n/a	9.8	37
University of Karachi					Assay Description Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...				Bioorg Chem 71: 10-18 (2017) Article DOI: 10.1016/j.bioorg.2017.01.008 BindingDB Entry DOI: 10.7270/Q26Q1W36
University of Karachi					More data for this Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme (Bos taurus (Cattle))	BDBM50241179 ((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...) Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1 \|r,c:5\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.92E+4	n/a	n/a	n/a	n/a	n/a	n/a
Forman Christian College (A Chartered University) Curated by ChEMBL					Assay Description Inhibition of bovine kidney non-specific alkaline phosphatase using CDP-star chemiluminescent substrate assessed as change in luminescence by spectro...				Bioorg Med Chem 23: 2435-44 (2015) Article DOI: 10.1016/j.bmc.2015.03.054 BindingDB Entry DOI: 10.7270/Q2WW7KC8
					More data for this Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme (Bos taurus (Cattle))	BDBM50241179 ((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...) Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1 \|r,c:5\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.92E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£t Rostock Curated by ChEMBL					Assay Description Inhibition of bovine TNAP using CDP-star as substrate preincubated for 5 to 7 mins followed by substrate addition measured after 15 mins by spectroph...				Eur J Med Chem 126: 408-420 (2017) Article DOI: 10.1016/j.ejmech.2016.11.036 BindingDB Entry DOI: 10.7270/Q2DZ0BKR
Universit£t Rostock Curated by ChEMBL					More data for this Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme (Homo sapiens (Human))	BDBM50241179 ((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...) Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1 \|r,c:5\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Auckland Curated by ChEMBL					Assay Description Inhibition of human TNAP expressed in African green monkey COS7 cell membranes using CDP-star as substrate pretreated for 5 to 10 mins followed by su...				Eur J Med Chem 159: 282-291 (2018) Article DOI: 10.1016/j.ejmech.2018.09.063 BindingDB Entry DOI: 10.7270/Q23N263P
University of Auckland Curated by ChEMBL					More data for this Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme (Bos taurus (Cattle))	BDBM50241179 ((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...) Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1 \|r,c:5\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.02E+4	n/a	n/a	n/a	n/a	9.8	37
COMSATS Institute of Information Technology					Assay Description Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...				Bioorg Chem 70: 229-236 (2017) Article DOI: 10.1016/j.bioorg.2017.01.003 BindingDB Entry DOI: 10.7270/Q2K07334
COMSATS Institute of Information Technology					More data for this Ligand-Target Pair
Alkaline phosphatase, tissue-nonspecific isozyme (Homo sapiens (Human))	BDBM50241179 ((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...) Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1 \|r,c:5\| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.02E+4	n/a	n/a	n/a	n/a	n/a	n/a
Quaid-I-Azam University Curated by ChEMBL					Assay Description Inhibition of human TNAP expressed in COS7 cells using CDP-star as substrate preincubated for 5 to 10 mins followed by substrate addition measured af...				Eur J Med Chem 156: 461-478 (2018) Article DOI: 10.1016/j.ejmech.2018.07.002 BindingDB Entry DOI: 10.7270/Q21C20K3
Quaid-I-Azam University Curated by ChEMBL					More data for this Ligand-Target Pair