BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Alpha-2A adrenergic receptor' and Ligand = 'BDBM50263724'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alpha-2A adrenergic receptor (Homo sapiens (Human))	BDBM50263724 (1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-4-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	66	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization...				Bioorg Med Chem Lett 18: 5689-93 (2008) Article DOI: 10.1016/j.bmcl.2008.08.055 BindingDB Entry DOI: 10.7270/Q2N58M5Z
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Homo sapiens (Human))	BDBM50263724 (1-((2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methyl)-4-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	275	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Antagonist activity at human recombinant adrenergic alpha2A receptor expressed in CHO cells assessed as inhibition of NE-induced calcium mobilization...				Bioorg Med Chem Lett 18: 5689-93 (2008) Article DOI: 10.1016/j.bmcl.2008.08.055 BindingDB Entry DOI: 10.7270/Q2N58M5Z
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair