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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Amyloid-beta precursor protein' and Ligand = 'BDBM455346'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Amyloid-beta precursor protein


(Homo sapiens (Human))		BDBM455346
PNG
(7-(4-Fluorophenyl)-N4,5,5-trimethyl-N2-((1R,5S,8s)...)
Show SMILES CNc1nc(NC2C3CCC2CN(C3)c2ccnnc2)nc2N(CC(C)(C)c12)c1ccc(F)cc1 |TLB:5:6:12.11.13:8.9,14:12:6:8.9|
Show InChI InChI=1S/C26H31FN8/c1-26(2)15-35(19-8-6-18(27)7-9-19)24-21(26)23(28-3)32-25(33-24)31-22-16-4-5-17(22)14-34(13-16)20-10-11-29-30-12-20/h6-12,16-17,22H,4-5,13-15H2,1-3H3,(H2,28,31,32,33)
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US Patent
n/an/an/an/a 19n/an/an/an/a



HOFFMANN-LA ROCHE, INC.

US Patent


Assay Description
Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...

US Patent US10730881 (2020)


BindingDB Entry DOI: 10.7270/Q27M0C0J
More data for this
Ligand-Target Pair