Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Amyloid-beta precursor protein [672-711]' and Ligand = 'BDBM50129276'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Amyloid-beta precursor protein [672-711] (Homo sapiens (Human))	BDBM50129276 (CHEMBL3629737 | US9464103, (6aR,10aS)-10a-(4-chlor...) Show SMILES CC1(C)OCC2(CCC[C@@]3([C@H]2COc2c(F)ccc(F)c32)S(=O)(=O)c2ccc(Cl)cc2)CO1 Show InChI InChI=1S/C24H25ClF2O5S/c1-22(2)31-13-23(14-32-22)10-3-11-24(33(28,29)16-6-4-15(25)5-7-16)19(23)12-30-21-18(27)9-8-17(26)20(21)24/h4-9,19H,3,10-14H2,1-2H3/t19-,24-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	66.6	n/a	n/a	n/a	n/a	7.0	n/a
MERCK SHARP & DOHME CORP. US Patent					Assay Description To measure γ-secretase activity, membranes were incubated at 37° C. for 1 h in 50 μL of buffer containing 20 mM Hepes (pH 7.0) and 2 mM EDT...				US Patent US9464103 (2016) BindingDB Entry DOI: 10.7270/Q2NS0STQ
					More data for this Ligand-Target Pair