BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Amyloid-beta precursor protein [672-713]' and Ligand = 'BDBM446529'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Amyloid-beta precursor protein [672-713]


(Homo sapiens (Human))		BDBM446529
PNG
(7-(2,4-Difluorophenyl)-N2-(3-methoxy-4-(3-methyl-1...)
Show SMILES CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(C)n2)nc2N(CC(C)(C)c12)c1ccc(F)cc1F
Show InChI InChI=1S/C25H26F2N8O/c1-14-29-13-35(33-14)19-9-7-16(11-20(19)36-5)30-24-31-22(28-4)21-23(32-24)34(12-25(21,2)3)18-8-6-15(26)10-17(18)27/h6-11,13H,12H2,1-5H3,(H2,28,30,31,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 8n/an/an/an/a



HOFFMANN-LA ROCHE INC.

US Patent


Assay Description
Human neuroglioma H4 cells overexpressing human APP695 with the Swedish double mutation (K595N/M596L) were plated at 30,000 cells/well/100 μl in...

US Patent US10669276 (2020)


BindingDB Entry DOI: 10.7270/Q2BZ6928
More data for this
Ligand-Target Pair