Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Angiopoietin-1 receptor (Homo sapiens (Human)) | BDBM14983 (4-Methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyrid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of Tie2 (unknown origin) | Bioorg Med Chem Lett 19: 424-7 (2008) Article DOI: 10.1016/j.bmcl.2008.11.056 BindingDB Entry DOI: 10.7270/Q29P31HK | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Angiopoietin-1 receptor (Homo sapiens (Human)) | BDBM14983 (4-Methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyrid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Amgen | Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor... | J Med Chem 50: 611-26 (2007) Article DOI: 10.1021/jm061107l BindingDB Entry DOI: 10.7270/Q2MC8X8S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |