Found 9 hits Enz. Inhib. hit(s) with Target = 'Apelin receptor' and Ligand = 'BDBM269713' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apelin receptor
(Homo sapiens (Human)) | BDBM269713
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)Show SMILES CCNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:19.20,(-5.04,2.44,;-5.81,1.1,;-7.35,1.1,;-8.12,2.44,;-9.66,2.44,;-7.35,3.77,;-8.12,5.1,;-7.35,6.44,;-5.81,6.44,;-5.04,5.1,;-5.81,3.77,;-3.5,5.1,;-3.02,3.64,;-1.48,3.64,;-1.01,5.1,;.32,5.87,;1.66,5.1,;.89,3.77,;2.43,3.77,;2.99,5.87,;2.99,7.41,;4.33,5.1,;5.66,5.87,;6.99,5.1,;8.33,5.87,;8.33,7.41,;9.66,8.18,;6.99,8.18,;5.66,7.41,;-2.25,6.01,;-2.25,7.55,;-3.59,8.32,;-4.92,7.55,;-6.26,8.32,;-3.59,9.86,;-2.25,10.63,;-.92,9.86,;-.92,8.32,;.41,7.55,;1.75,8.32,)| Show InChI InChI=1S/C25H27FN8O5S/c1-5-27-24(35)18-9-6-8-17(30-18)23-31-32-25(34(23)22-19(38-3)10-7-11-20(22)39-4)33-40(36,37)15(2)12-21-28-13-16(26)14-29-21/h6-11,13-15H,5,12H2,1-4H3,(H,27,35)(H,32,33)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5.30 | n/a | n/a | 7.5 | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si... |
US Patent US10058550 (2018)
BindingDB Entry DOI: 10.7270/Q26T0PP0 |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269713
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)Show SMILES CCNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:19.20,(-5.04,2.44,;-5.81,1.1,;-7.35,1.1,;-8.12,2.44,;-9.66,2.44,;-7.35,3.77,;-8.12,5.1,;-7.35,6.44,;-5.81,6.44,;-5.04,5.1,;-5.81,3.77,;-3.5,5.1,;-3.02,3.64,;-1.48,3.64,;-1.01,5.1,;.32,5.87,;1.66,5.1,;.89,3.77,;2.43,3.77,;2.99,5.87,;2.99,7.41,;4.33,5.1,;5.66,5.87,;6.99,5.1,;8.33,5.87,;8.33,7.41,;9.66,8.18,;6.99,8.18,;5.66,7.41,;-2.25,6.01,;-2.25,7.55,;-3.59,8.32,;-4.92,7.55,;-6.26,8.32,;-3.59,9.86,;-2.25,10.63,;-.92,9.86,;-.92,8.32,;.41,7.55,;1.75,8.32,)| Show InChI InChI=1S/C25H27FN8O5S/c1-5-27-24(35)18-9-6-8-17(30-18)23-31-32-25(34(23)22-19(38-3)10-7-11-20(22)39-4)33-40(36,37)15(2)12-21-28-13-16(26)14-29-21/h6-11,13-15H,5,12H2,1-4H3,(H,27,35)(H,32,33)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 6.30 | n/a | n/a | 7.5 | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si... |
US Patent US10058550 (2018)
BindingDB Entry DOI: 10.7270/Q26T0PP0 |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269713
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)Show SMILES CCNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:19.20,(-5.04,2.44,;-5.81,1.1,;-7.35,1.1,;-8.12,2.44,;-9.66,2.44,;-7.35,3.77,;-8.12,5.1,;-7.35,6.44,;-5.81,6.44,;-5.04,5.1,;-5.81,3.77,;-3.5,5.1,;-3.02,3.64,;-1.48,3.64,;-1.01,5.1,;.32,5.87,;1.66,5.1,;.89,3.77,;2.43,3.77,;2.99,5.87,;2.99,7.41,;4.33,5.1,;5.66,5.87,;6.99,5.1,;8.33,5.87,;8.33,7.41,;9.66,8.18,;6.99,8.18,;5.66,7.41,;-2.25,6.01,;-2.25,7.55,;-3.59,8.32,;-4.92,7.55,;-6.26,8.32,;-3.59,9.86,;-2.25,10.63,;-.92,9.86,;-.92,8.32,;.41,7.55,;1.75,8.32,)| Show InChI InChI=1S/C25H27FN8O5S/c1-5-27-24(35)18-9-6-8-17(30-18)23-31-32-25(34(23)22-19(38-3)10-7-11-20(22)39-4)33-40(36,37)15(2)12-21-28-13-16(26)14-29-21/h6-11,13-15H,5,12H2,1-4H3,(H,27,35)(H,32,33)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.20 | n/a | n/a | 7.5 | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV¿-3 expression vector (Si... |
US Patent US10058550 (2018)
BindingDB Entry DOI: 10.7270/Q26T0PP0 |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269713
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)Show SMILES CCNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:19.20,(-5.04,2.44,;-5.81,1.1,;-7.35,1.1,;-8.12,2.44,;-9.66,2.44,;-7.35,3.77,;-8.12,5.1,;-7.35,6.44,;-5.81,6.44,;-5.04,5.1,;-5.81,3.77,;-3.5,5.1,;-3.02,3.64,;-1.48,3.64,;-1.01,5.1,;.32,5.87,;1.66,5.1,;.89,3.77,;2.43,3.77,;2.99,5.87,;2.99,7.41,;4.33,5.1,;5.66,5.87,;6.99,5.1,;8.33,5.87,;8.33,7.41,;9.66,8.18,;6.99,8.18,;5.66,7.41,;-2.25,6.01,;-2.25,7.55,;-3.59,8.32,;-4.92,7.55,;-6.26,8.32,;-3.59,9.86,;-2.25,10.63,;-.92,9.86,;-.92,8.32,;.41,7.55,;1.75,8.32,)| Show InChI InChI=1S/C25H27FN8O5S/c1-5-27-24(35)18-9-6-8-17(30-18)23-31-32-25(34(23)22-19(38-3)10-7-11-20(22)39-4)33-40(36,37)15(2)12-21-28-13-16(26)14-29-21/h6-11,13-15H,5,12H2,1-4H3,(H,27,35)(H,32,33)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269713
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)Show SMILES CCNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:19.20,(-5.04,2.44,;-5.81,1.1,;-7.35,1.1,;-8.12,2.44,;-9.66,2.44,;-7.35,3.77,;-8.12,5.1,;-7.35,6.44,;-5.81,6.44,;-5.04,5.1,;-5.81,3.77,;-3.5,5.1,;-3.02,3.64,;-1.48,3.64,;-1.01,5.1,;.32,5.87,;1.66,5.1,;.89,3.77,;2.43,3.77,;2.99,5.87,;2.99,7.41,;4.33,5.1,;5.66,5.87,;6.99,5.1,;8.33,5.87,;8.33,7.41,;9.66,8.18,;6.99,8.18,;5.66,7.41,;-2.25,6.01,;-2.25,7.55,;-3.59,8.32,;-4.92,7.55,;-6.26,8.32,;-3.59,9.86,;-2.25,10.63,;-.92,9.86,;-.92,8.32,;.41,7.55,;1.75,8.32,)| Show InChI InChI=1S/C25H27FN8O5S/c1-5-27-24(35)18-9-6-8-17(30-18)23-31-32-25(34(23)22-19(38-3)10-7-11-20(22)39-4)33-40(36,37)15(2)12-21-28-13-16(26)14-29-21/h6-11,13-15H,5,12H2,1-4H3,(H,27,35)(H,32,33)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269713
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)Show SMILES CCNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:19.20,(-5.04,2.44,;-5.81,1.1,;-7.35,1.1,;-8.12,2.44,;-9.66,2.44,;-7.35,3.77,;-8.12,5.1,;-7.35,6.44,;-5.81,6.44,;-5.04,5.1,;-5.81,3.77,;-3.5,5.1,;-3.02,3.64,;-1.48,3.64,;-1.01,5.1,;.32,5.87,;1.66,5.1,;.89,3.77,;2.43,3.77,;2.99,5.87,;2.99,7.41,;4.33,5.1,;5.66,5.87,;6.99,5.1,;8.33,5.87,;8.33,7.41,;9.66,8.18,;6.99,8.18,;5.66,7.41,;-2.25,6.01,;-2.25,7.55,;-3.59,8.32,;-4.92,7.55,;-6.26,8.32,;-3.59,9.86,;-2.25,10.63,;-.92,9.86,;-.92,8.32,;.41,7.55,;1.75,8.32,)| Show InChI InChI=1S/C25H27FN8O5S/c1-5-27-24(35)18-9-6-8-17(30-18)23-31-32-25(34(23)22-19(38-3)10-7-11-20(22)39-4)33-40(36,37)15(2)12-21-28-13-16(26)14-29-21/h6-11,13-15H,5,12H2,1-4H3,(H,27,35)(H,32,33)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269713
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)Show SMILES CCNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:19.20,(-5.04,2.44,;-5.81,1.1,;-7.35,1.1,;-8.12,2.44,;-9.66,2.44,;-7.35,3.77,;-8.12,5.1,;-7.35,6.44,;-5.81,6.44,;-5.04,5.1,;-5.81,3.77,;-3.5,5.1,;-3.02,3.64,;-1.48,3.64,;-1.01,5.1,;.32,5.87,;1.66,5.1,;.89,3.77,;2.43,3.77,;2.99,5.87,;2.99,7.41,;4.33,5.1,;5.66,5.87,;6.99,5.1,;8.33,5.87,;8.33,7.41,;9.66,8.18,;6.99,8.18,;5.66,7.41,;-2.25,6.01,;-2.25,7.55,;-3.59,8.32,;-4.92,7.55,;-6.26,8.32,;-3.59,9.86,;-2.25,10.63,;-.92,9.86,;-.92,8.32,;.41,7.55,;1.75,8.32,)| Show InChI InChI=1S/C25H27FN8O5S/c1-5-27-24(35)18-9-6-8-17(30-18)23-31-32-25(34(23)22-19(38-3)10-7-11-20(22)39-4)33-40(36,37)15(2)12-21-28-13-16(26)14-29-21/h6-11,13-15H,5,12H2,1-4H3,(H,27,35)(H,32,33)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269713
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)Show SMILES CCNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:19.20,(-5.04,2.44,;-5.81,1.1,;-7.35,1.1,;-8.12,2.44,;-9.66,2.44,;-7.35,3.77,;-8.12,5.1,;-7.35,6.44,;-5.81,6.44,;-5.04,5.1,;-5.81,3.77,;-3.5,5.1,;-3.02,3.64,;-1.48,3.64,;-1.01,5.1,;.32,5.87,;1.66,5.1,;.89,3.77,;2.43,3.77,;2.99,5.87,;2.99,7.41,;4.33,5.1,;5.66,5.87,;6.99,5.1,;8.33,5.87,;8.33,7.41,;9.66,8.18,;6.99,8.18,;5.66,7.41,;-2.25,6.01,;-2.25,7.55,;-3.59,8.32,;-4.92,7.55,;-6.26,8.32,;-3.59,9.86,;-2.25,10.63,;-.92,9.86,;-.92,8.32,;.41,7.55,;1.75,8.32,)| Show InChI InChI=1S/C25H27FN8O5S/c1-5-27-24(35)18-9-6-8-17(30-18)23-31-32-25(34(23)22-19(38-3)10-7-11-20(22)39-4)33-40(36,37)15(2)12-21-28-13-16(26)14-29-21/h6-11,13-15H,5,12H2,1-4H3,(H,27,35)(H,32,33)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig... |
US Patent US9845310 (2017)
BindingDB Entry DOI: 10.7270/Q28P62TV |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM269713
(6-(4-(2,6-dimethoxyphenyl)-5-((((1S)-2-(5-fluoro-2...)Show SMILES CCNC(=O)c1cccc(n1)-c1nnc(NS(=O)(=O)[C@@H](C)Cc2ncc(F)cn2)n1-c1c(OC)cccc1OC |r,wU:19.20,(-5.04,2.44,;-5.81,1.1,;-7.35,1.1,;-8.12,2.44,;-9.66,2.44,;-7.35,3.77,;-8.12,5.1,;-7.35,6.44,;-5.81,6.44,;-5.04,5.1,;-5.81,3.77,;-3.5,5.1,;-3.02,3.64,;-1.48,3.64,;-1.01,5.1,;.32,5.87,;1.66,5.1,;.89,3.77,;2.43,3.77,;2.99,5.87,;2.99,7.41,;4.33,5.1,;5.66,5.87,;6.99,5.1,;8.33,5.87,;8.33,7.41,;9.66,8.18,;6.99,8.18,;5.66,7.41,;-2.25,6.01,;-2.25,7.55,;-3.59,8.32,;-4.92,7.55,;-6.26,8.32,;-3.59,9.86,;-2.25,10.63,;-.92,9.86,;-.92,8.32,;.41,7.55,;1.75,8.32,)| Show InChI InChI=1S/C25H27FN8O5S/c1-5-27-24(35)18-9-6-8-17(30-18)23-31-32-25(34(23)22-19(38-3)10-7-11-20(22)39-4)33-40(36,37)15(2)12-21-28-13-16(26)14-29-21/h6-11,13-15H,5,12H2,1-4H3,(H,27,35)(H,32,33)/t15-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | n/a | n/a | 6.30 | n/a | n/a | n/a | n/a |
AMGEN INC.
US Patent
| Assay Description
The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV™-3 expression vector (Si... |
US Patent US10221162 (2019)
BindingDB Entry DOI: 10.7270/Q2ZK5JXS |
More data for this
Ligand-Target Pair | |
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