Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177863'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177863 (US9120791, Example 85 | US9603854, 85) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccsc1 Show InChI InChI=1S/C40H39ClN4O4S/c41-29-8-13-34(39(47)44-24-28-6-2-1-5-27(28)21-32(44)25-42-16-18-49-19-17-42)35(22-29)38-23-36(37-7-3-4-15-43(37)38)40(48)45(31-14-20-50-26-31)30-9-11-33(46)12-10-30/h1-2,5-6,8-14,20,22-23,26,32,46H,3-4,7,15-19,21,24-25H2/t32-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177863 (US9120791, Example 85 | US9603854, 85) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1ccsc1 Show InChI InChI=1S/C40H39ClN4O4S/c41-29-8-13-34(39(47)44-24-28-6-2-1-5-27(28)21-32(44)25-42-16-18-49-19-17-42)35(22-29)38-23-36(37-7-3-4-15-43(37)38)40(48)45(31-14-20-50-26-31)30-9-11-33(46)12-10-30/h1-2,5-6,8-14,20,22-23,26,32,46H,3-4,7,15-19,21,24-25H2/t32-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	41	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair