Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177872'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177872 (US9120791, Example 98 | US9603854, 98) Show SMILES Cc1ccc(cc1F)N(C(=O)c1cc(-c2cc(F)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(O)cc1 Show InChI InChI=1S/C42H40F2N4O5/c1-27-6-8-32(22-38(27)44)48(31-9-11-34(49)12-10-31)42(51)37-23-39(46-16-19-53-26-40(37)46)36-21-30(43)7-13-35(36)41(50)47-24-29-5-3-2-4-28(29)20-33(47)25-45-14-17-52-18-15-45/h2-13,21-23,33,49H,14-20,24-26H2,1H3/t33-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177872 (US9120791, Example 98 | US9603854, 98) Show SMILES Cc1ccc(cc1F)N(C(=O)c1cc(-c2cc(F)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(O)cc1 Show InChI InChI=1S/C42H40F2N4O5/c1-27-6-8-32(22-38(27)44)48(31-9-11-34(49)12-10-31)42(51)37-23-39(46-16-19-53-26-40(37)46)36-21-30(43)7-13-35(36)41(50)47-24-29-5-3-2-4-28(29)20-33(47)25-45-14-17-52-18-15-45/h2-13,21-23,33,49H,14-20,24-26H2,1H3/t33-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair