Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177873'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177873 (US9120791, Example 99 | US9603854, 100) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(F)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(F)cc1 Show InChI InChI=1S/C41H38F2N4O5/c42-29-5-8-31(9-6-29)47(32-10-12-34(48)13-11-32)41(50)37-23-38(45-17-20-52-26-39(37)45)36-22-30(43)7-14-35(36)40(49)46-24-28-4-2-1-3-27(28)21-33(46)25-44-15-18-51-19-16-44/h1-14,22-23,33,48H,15-21,24-26H2/t33-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177873 (US9120791, Example 99 | US9603854, 100) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(F)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(F)cc1 Show InChI InChI=1S/C41H38F2N4O5/c42-29-5-8-31(9-6-29)47(32-10-12-34(48)13-11-32)41(50)37-23-38(45-17-20-52-26-39(37)45)36-22-30(43)7-14-35(36)40(49)46-24-28-4-2-1-3-27(28)21-33(46)25-44-15-18-51-19-16-44/h1-14,22-23,33,48H,15-21,24-26H2/t33-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177873 (US9120791, Example 99 | US9603854, 100) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(F)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(F)cc1 Show InChI InChI=1S/C41H38F2N4O5/c42-29-5-8-31(9-6-29)47(32-10-12-34(48)13-11-32)41(50)37-23-38(45-17-20-52-26-39(37)45)36-22-30(43)7-14-35(36)40(49)46-24-28-4-2-1-3-27(28)21-33(46)25-44-15-18-51-19-16-44/h1-14,22-23,33,48H,15-21,24-26H2/t33-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair