Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177875'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177875 (US9120791, Example 101 | US9603854, 101) Show SMILES Cn1ncc2cc(ccc12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(O)cc1 Show InChI InChI=1S/C43H41ClN6O5/c1-46-39-13-9-33(21-30(39)24-45-46)50(32-7-10-35(51)11-8-32)43(53)38-23-40(48-16-19-55-27-41(38)48)37-22-31(44)6-12-36(37)42(52)49-25-29-5-3-2-4-28(29)20-34(49)26-47-14-17-54-18-15-47/h2-13,21-24,34,51H,14-20,25-27H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177875 (US9120791, Example 101 | US9603854, 101) Show SMILES Cn1ncc2cc(ccc12)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCOCc12)c1ccc(O)cc1 Show InChI InChI=1S/C43H41ClN6O5/c1-46-39-13-9-33(21-30(39)24-45-46)50(32-7-10-35(51)11-8-32)43(53)38-23-40(48-16-19-55-27-41(38)48)37-22-31(44)6-12-36(37)42(52)49-25-29-5-3-2-4-28(29)20-34(49)26-47-14-17-54-18-15-47/h2-13,21-24,34,51H,14-20,25-27H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair