Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177893'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177893 (US9120791, Example 123 | US9603854, 123) Show SMILES CS(=O)(=O)N1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-c2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3CCCCn23)CC1 Show InChI InChI=1S/C44H45N5O7S/c1-57(53,54)46-21-19-45(20-22-46)28-34-23-30-9-5-6-10-31(30)27-48(34)43(51)37-26-42-41(55-29-56-42)25-36(37)40-24-38(39-13-7-8-18-47(39)40)44(52)49(32-11-3-2-4-12-32)33-14-16-35(50)17-15-33/h2-6,9-12,14-17,24-26,34,50H,7-8,13,18-23,27-29H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177893 (US9120791, Example 123 | US9603854, 123) Show SMILES CS(=O)(=O)N1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-c2cc(C(=O)N(c3ccccc3)c3ccc(O)cc3)c3CCCCn23)CC1 Show InChI InChI=1S/C44H45N5O7S/c1-57(53,54)46-21-19-45(20-22-46)28-34-23-30-9-5-6-10-31(30)27-48(34)43(51)37-26-42-41(55-29-56-42)25-36(37)40-24-38(39-13-7-8-18-47(39)40)44(52)49(32-11-3-2-4-12-32)33-14-16-35(50)17-15-33/h2-6,9-12,14-17,24-26,34,50H,7-8,13,18-23,27-29H2,1H3/t34-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair