Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177895'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177895 (US9120791, Example 125 | US9603854, 125) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1cc(F)cc(F)c1 Show InChI InChI=1S/C42H39ClF2N4O4/c43-29-8-13-36(41(51)48-25-28-6-2-1-5-27(28)19-34(48)26-46-15-17-53-18-16-46)37(20-29)40-24-38(39-7-3-4-14-47(39)40)42(52)49(32-9-11-35(50)12-10-32)33-22-30(44)21-31(45)23-33/h1-2,5-6,8-13,20-24,34,50H,3-4,7,14-19,25-26H2/t34-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177895 (US9120791, Example 125 | US9603854, 125) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1cc(F)cc(F)c1 Show InChI InChI=1S/C42H39ClF2N4O4/c43-29-8-13-36(41(51)48-25-28-6-2-1-5-27(28)19-34(48)26-46-15-17-53-18-16-46)37(20-29)40-24-38(39-7-3-4-14-47(39)40)42(52)49(32-9-11-35(50)12-10-32)33-22-30(44)21-31(45)23-33/h1-2,5-6,8-13,20-24,34,50H,3-4,7,14-19,25-26H2/t34-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	38	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair