Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM177900'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Homo sapiens (Human))	BDBM177900 (US9120791, Example 131 | US9603854, 131) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1cccc(Cl)c1 Show InChI InChI=1S/C42H40Cl2N4O4/c43-30-8-5-9-33(23-30)48(32-12-14-35(49)15-13-32)42(51)38-25-40(46-17-4-3-10-39(38)46)37-24-31(44)11-16-36(37)41(50)47-26-29-7-2-1-6-28(29)22-34(47)27-45-18-20-52-21-19-45/h1-2,5-9,11-16,23-25,34,49H,3-4,10,17-22,26-27H2/t34-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9603854 (2017) BindingDB Entry DOI: 10.7270/Q2GX4DMT
					More data for this Ligand-Target Pair
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM177900 (US9120791, Example 131 | US9603854, 131) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2cc(Cl)ccc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)n2CCCCc12)c1cccc(Cl)c1 Show InChI InChI=1S/C42H40Cl2N4O4/c43-30-8-5-9-33(23-30)48(32-12-14-35(49)15-13-32)42(51)38-25-40(46-17-4-3-10-39(38)46)37-24-31(44)11-16-36(37)41(50)47-26-29-7-2-1-6-28(29)22-34(47)27-45-18-20-52-21-19-45/h1-2,5-9,11-16,23-25,34,49H,3-4,10,17-22,26-27H2/t34-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
					More data for this Ligand-Target Pair