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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM50261499'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM50261499
PNG
(CHEMBL4088564)
Show SMILES COc1ccc(cc1)S(=O)(=O)NC(=O)Cc1c(C)n(-c2ccc(C)cc2)c2ccc(OC)cc12
Show InChI InChI=1S/C26H26N2O5S/c1-17-5-7-19(8-6-17)28-18(2)23(24-15-21(33-4)11-14-25(24)28)16-26(29)27-34(30,31)22-12-9-20(32-3)10-13-22/h5-15H,16H2,1-4H3,(H,27,29)
PDB

UniProtKB/SwissProt

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PC cid
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UniChem

Similars
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of 5-FAM-Bid-BH3 peptide binding to Bcl2 (unknown origin) pre-incubated for 30 mins followed by further incubation with 5-FAM-Bid-BH3 pept...

Bioorg Med Chem 25: 5548-5556 (2017)


Article DOI: 10.1016/j.bmc.2017.08.024
BindingDB Entry DOI: 10.7270/Q2FX7CX8
More data for this
Ligand-Target Pair