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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM50261529'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Apoptosis regulator Bcl-2


(Homo sapiens (Human))		BDBM50261529
PNG
(CHEMBL4076908)
Show SMILES COc1ccc2n(c(C)c(CC(=O)NS(=O)(=O)c3ccc(Cl)c(c3)[N+]([O-])=O)c2c1)-c1ccc(C)cc1
Show InChI InChI=1S/C25H22ClN3O6S/c1-15-4-6-17(7-5-15)28-16(2)20(21-12-18(35-3)8-11-23(21)28)14-25(30)27-36(33,34)19-9-10-22(26)24(13-19)29(31)32/h4-13H,14H2,1-3H3,(H,27,30)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.00E+4n/an/an/an/an/an/an/an/a



Shandong University

Curated by ChEMBL


Assay Description
Inhibition of 5-FAM-Bid-BH3 peptide binding to Bcl2 (unknown origin) pre-incubated for 30 mins followed by further incubation with 5-FAM-Bid-BH3 pept...

Bioorg Med Chem 25: 5548-5556 (2017)


Article DOI: 10.1016/j.bmc.2017.08.024
BindingDB Entry DOI: 10.7270/Q2FX7CX8
More data for this
Ligand-Target Pair