Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Apoptosis regulator Bcl-2' and Ligand = 'BDBM60598'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apoptosis regulator Bcl-2 (Mus musculus (Mouse))	BDBM60598 (US9120791, 109) Show SMILES Oc1ccc(cc1)N(C(=O)c1cc(-c2ccc3OCOc3c2C(=O)N2Cc3ccccc3C[C@H]2CON2CCOCC2)n2CCCCc12)c1ccccc1 Show InChI InChI=1S/C43H42N4O7/c48-34-15-13-32(14-16-34)47(31-10-2-1-3-11-31)42(49)36-25-38(45-19-7-6-12-37(36)45)35-17-18-39-41(53-28-52-39)40(35)43(50)46-26-30-9-5-4-8-29(30)24-33(46)27-54-44-20-22-51-23-21-44/h1-5,8-11,13-18,25,33,48H,6-7,12,19-24,26-28H2/t33-/m0/s1	PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.4	n/a
LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD US Patent					Assay Description The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, at a final concentration of 2.50×10−8 M, is...				US Patent US9120791 (2015) BindingDB Entry DOI: 10.7270/Q21N7ZWC
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