Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Arachidonate 5-lipoxygenase-activating protein' and Ligand = 'BDBM145778'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145778 (US8952177, 132 | US9089569, 132 | US9695149, 132) Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4[C@H](C(O)=O)C4(C)C)n(Cc4ccc(Br)cc4)c3c2)c(F)c1 |r| Show InChI InChI=1S/C27H25BrFN3O3/c1-15-10-19(29)21(30-12-15)14-35-18-8-9-20-22(11-18)32(13-16-4-6-17(28)7-5-16)25(31-20)23-24(26(33)34)27(23,2)3/h4-12,23-24H,13-14H2,1-3H3,(H,33,34)/t23-,24+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145778 (US8952177, 132 | US9089569, 132 | US9695149, 132) Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4[C@H](C(O)=O)C4(C)C)n(Cc4ccc(Br)cc4)c3c2)c(F)c1 |r| Show InChI InChI=1S/C27H25BrFN3O3/c1-15-10-19(29)21(30-12-15)14-35-18-8-9-20-22(11-18)32(13-16-4-6-17(28)7-5-16)25(31-20)23-24(26(33)34)27(23,2)3/h4-12,23-24H,13-14H2,1-3H3,(H,33,34)/t23-,24+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9695149 (2017) BindingDB Entry DOI: 10.7270/Q2Q52MSC
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145778 (US8952177, 132 | US9089569, 132 | US9695149, 132) Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4[C@H](C(O)=O)C4(C)C)n(Cc4ccc(Br)cc4)c3c2)c(F)c1 |r| Show InChI InChI=1S/C27H25BrFN3O3/c1-15-10-19(29)21(30-12-15)14-35-18-8-9-20-22(11-18)32(13-16-4-6-17(28)7-5-16)25(31-20)23-24(26(33)34)27(23,2)3/h4-12,23-24H,13-14H2,1-3H3,(H,33,34)/t23-,24+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9089569 (2015) BindingDB Entry DOI: 10.7270/Q23X85DB
					More data for this Ligand-Target Pair