Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Arachidonate 5-lipoxygenase-activating protein' and Ligand = 'BDBM145784'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145784 (US8952177, 138 | US9089569, 138 | US9695149, 138) Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4c(F)cc(cc4F)-c4ccc(cc4)C(F)(F)F)c3c2)nc1 |r| Show InChI InChI=1S/C35H30F5N3O3/c1-20-6-11-24(41-17-20)19-46-25-12-13-31-32(16-25)43(33(42-31)26-4-2-3-5-27(26)34(44)45)18-28-29(36)14-22(15-30(28)37)21-7-9-23(10-8-21)35(38,39)40/h6-17,26-27H,2-5,18-19H2,1H3,(H,44,45)/t26-,27+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145784 (US8952177, 138 | US9089569, 138 | US9695149, 138) Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4c(F)cc(cc4F)-c4ccc(cc4)C(F)(F)F)c3c2)nc1 |r| Show InChI InChI=1S/C35H30F5N3O3/c1-20-6-11-24(41-17-20)19-46-25-12-13-31-32(16-25)43(33(42-31)26-4-2-3-5-27(26)34(44)45)18-28-29(36)14-22(15-30(28)37)21-7-9-23(10-8-21)35(38,39)40/h6-17,26-27H,2-5,18-19H2,1H3,(H,44,45)/t26-,27+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9695149 (2017) BindingDB Entry DOI: 10.7270/Q2Q52MSC
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145784 (US8952177, 138 | US9089569, 138 | US9695149, 138) Show SMILES Cc1ccc(COc2ccc3nc([C@H]4CCCC[C@H]4C(O)=O)n(Cc4c(F)cc(cc4F)-c4ccc(cc4)C(F)(F)F)c3c2)nc1 |r| Show InChI InChI=1S/C35H30F5N3O3/c1-20-6-11-24(41-17-20)19-46-25-12-13-31-32(16-25)43(33(42-31)26-4-2-3-5-27(26)34(44)45)18-28-29(36)14-22(15-30(28)37)21-7-9-23(10-8-21)35(38,39)40/h6-17,26-27H,2-5,18-19H2,1H3,(H,44,45)/t26-,27+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9089569 (2015) BindingDB Entry DOI: 10.7270/Q23X85DB
					More data for this Ligand-Target Pair